Human Esophageal Smooth Muscle Cells (HESMC)

Cat.No.: CSC-7781W

Species: Human

Source: Esophagus

Cell Type: Smooth Muscle

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Cat.No.

CSC-7781W

Description

Smooth muscle is responsible for the contractility of hollow organs, such as blood vessels, the gastrointestinal tract, the bladder, and the uterus. Its structure differs greatly from that of skeletal muscle. The human esophagus contains three layers of muscle in its walls, the outer longitudinal and inner circular layers of the main muscular coat and the muscular layer of the mucosa. Visceral smooth muscle cells makes up all three layers along the entire organ except for the most rostral few centimeters. Smooth muscle contraction is critical to peristalsis in the human esophagus and the contraction may be mediated by activation of phospholipase through two distinct mechanisms (increased intracellular Ca2+ and G protein activation) and activating PKCepsilon-dependent mechanisms. In vitro study also shows that cultured human esophageal smooth muscle cells express voltage-dependent Na(+) channels.HESMC from Bioarray Research Laboratories are isolated from the human esophagus. HESMC are cryopreserved at secondary culture and delivered frozen. Each vial contains >5 x 10^5 cells in 1 ml volume. HESMC are characterized by immunofluorescent method with antibodies to &ALPHA;-smooth muscle actin and desmin. HESMC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HESMC are guaranteed to further expand for 15 population doublings at the condition provided by Bioarray Research Laboratories.

Species

Human

Source

Esophagus

Cell Type

Smooth Muscle

Disease

Normal

Storage and Shipping

Directly and immediately transfer cells from dry ice to liquid nitrogen upon receiving and keep the cells in liquid nitrogen until cell culture needed for experiments.

Citation Guidance

If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.

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Human Esophageal Fibroblasts (HEF)

Description: The HEF cells from Creative Bioarray are isolated from human esophageal tissue. HEF are cryopreserved at passage one and delivered frozen. Each vial contains >5 x 10^5 cells in 1 ml volume. HEF are characterized by immunofluorescence with antibody specific to fibronectin. HEF are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HEF are guaranteed to further expand for 15 population doublings at the conditions provided by Creative Bioarray.

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Human Esophageal Epithelial Cells (HEEpiC)

Description: The human esophagus is lined by a non-keratinizing, moist stratified squamous epithelium whose apical cell membranes and intercellular junctional complexes combine to produce an effective permeability barrier against the influx of luminal content. In particular, the barrier created by these structures limits exposure of the surface cells' basolateral cell membranes and entire membrane of cells of the deeper layers to the wide swings in osmolality occurring regularly within the esophageal lumen. Histologically, the esophageal epithelium consists of two zones, the basal and differentiated zones. Cellular proliferation is limited to the basal zone, and cells are thought to migrate from this area towards the esophageal lumen. Migration is associated with the initiation of differentiation and the sequential expression of differentiation markers. The availability of human esophageal epithelial cell culture provides an excellent in vitro model in the study of the physiology of esophageal epithelium and the mechanisms of the esophageal carcinogenesis.HEEC from Bioarray Research Laboratories are isolated from the human esophagus. HEEC are cryopreserved on passage one culture and delivered frozen. Each vial contains >5 x 10^5 cells in 1 ml volume. HEEC are characterized by immunofluorescent method with antibodies to cytokeratine-8, -18 and -19. HEEC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HEEC are guaranteed to further expand for 15 population doublings in the condition provided by Bioarray Research Laboratories.

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Human Esophageal Microvascular Endothelial Cells

Description: HEMEC from Creative Bioarray are isolated from human esophageal tissue. HEMEC are cryopreserved at passage one and delivered frozen. Each vial contains >5 x 10^5 cells in 1 ml volume. HEMEC are characterized by immunofluorescent method with antibodies to vWF/Factor VIII and CD31 (P-CAM) and by uptake of DiI-Ac-LDL. HEMEC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HEMEC are guaranteed to further culture in the conditions provided by Creative Bioarray.

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For research use only. Not for any other purpose.