Circulating Tumor Cell (CTC) FISH

Circulating tumor cells (CTCs) represent a pivotal element in cancer research, as they offer an unparalleled, non-invasive method to explore the intricacies of tumor biology. CTCs originate from primary tumors and enter the bloodstream, with most undergoing rapid apoptosis during circulation. However, a select few survive and may precipitate distant metastatic diseases. These cells hold irreplaceable significance in diagnosis, prognosis prediction, and therapeutic monitoring.

Fig. 1. Entrance of CTCs into the circulation: Tumors release CTCs into the circulation (Agashe R and Kurzrock R, 2020).

The CTC FISH (fluorescence in situ hybridization) method provides high resolution genomic mapping of circulating tumour cells. Detecting gene mutations or chromosomal aberrations in cancer cells, using CTC FISH, enables tumour molecular structures to be determined down to the cell level. This is used to identify CTCs in patients with breast, prostate and colorectal cancers from a genomic-wide perspective. Moreover, CTC FISH not only determines the metastatic potential of cancers, but also offers valuable information to identify targets for treatment.

Creative Bioarray offers circulating tumor cell (CTC) FISH services aimed at the precise detection and analysis of circulating tumor cells using state-of-the-art FISH technology.

Advantages of CTC FISH technology:

High sensitivity and specificity: The CTC FISH technology offers superior sensitivity and specificity compared to traditional cytology and conventional CK staining, enabling precise detection and enumeration of CTCs.
Comprehensive detection and typing: Beyond CTC quantification, this technology facilitates molecular typing, providing essential insights for precision oncology.
Non-invasive testing: With only a small peripheral blood sample required, this method is non-invasive, causing no adverse effects and allowing for regular monitoring and real-time personalized treatment planning.
Multiplexing capability: CTC FISH can concurrently identify multiple target genes or chromosomal abnormalities, delivering extensive genetic information.

Creative Bioarray's CTC FISH Service Process:

Sample collection and preparation: Creative Bioarray supplies expert guidelines to assist clients in the effective collection of blood samples, ensuring high-quality sample integrity and optimal cellular conditions.
CTCs enrichment and isolation: Through advanced microfluidic and negative enrichment technologies, we tailor our enrichment strategies to specific sample requirements, efficiently removing leukocytes, erythrocytes, and plasma proteins to concentrate CTCs.
FISH detection: Through FISH technology, we detect specific genetic and chromosomal anomalies in enriched CTCs.
Data interpretation and reporting: We offer high-quality images of stained CTCs and integrate FISH data with other molecular data for a comprehensive perspective of your samples.
Technical support: Our expert team is always available to provide technical support and consultation services, ensuring the smooth progression of your research.

Why Choose Creative Bioarray's CTC FISH Services?

One-stop service: From sample collection, CTCs enrichment and isolation, identification and typing, image scanning and analysis to data interpretation—our comprehensive one-stop service simplifies and expedites the process.
Advanced technology: We employ the latest CTC enrichment methods and FISH technologies, ensuring high-quality results.
High sensitivity detection: Our CTC FISH service can detect extremely low-abundance CTCs, even in early-stage cancer patients.
Expert team: Our team consists of seasoned professionals with deep expertise in cancer research and cellular analysis, assuring the highest standards of service and reliability.
Comprehensive customer support: From initial consultation to the final report, Creative Bioarray provide extensive support and service to ensure efficient and successful collaboration.

FAQ

1. How much sample is required for CTC FISH analysis?

We typically recommend at least 10 milliliters of blood to ensure sufficient CTCs for analysis.

2. Is this service applicable to all cancer types?

Creative Bioarray's CTC FISH service is applicable to various cancer types, but its specific applicability may depend on the genetic characteristics of the cancer. We recommend discussing your specific research needs with our technical experts.

3. How do you ensure accuracy of the results?

We implement multiple quality control measures and utilize validated protocols and probes to ensure the accuracy and reliability of results.

4. How long does it take to obtain results?

Creative Bioarray's standard turnaround time is approximately two weeks from sample receipt.

Quotation and Ordering

For more information about our CTC FISH services or to schedule testing, please visit our official website or contact our customer service team. We look forward to providing you with professional, accurate, and reliable cancer testing services.

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For research use only. Not for any other purpose.