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Diabetic Nephropathy (DN) Models
Creative Bioarray provides in vivo pharmacodynamics studies in validated, well-established animal models of diabetic nephropathy (DN), which is useful in the rapid evaluation of a test compound's efficacy. According to your unique requirements, our scientists will partner with you to assist you from initial study design to final reporting and analysis of your data to provide you with reliable, reproducible results.
DN is the leading cause of kidney failure worldwide; in the USA, it accounts for over 50% of individuals entering dialysis or transplant programs. Unlike other complications of diabetes, the prevalence of diabetic kidney disease has failed to decline over the past 30 years. Hyperglycaemia is the primary aetiological factor responsible for the development of DN. Once hyperglycaemia becomes established, multiple pathophysiological disturbances, including glomerulosclerosis, mesangial expansion, podocyte loss and tubulointerstitial damage. The clinical manifestation of these effects is a progressive decline in kidney function, accompanied by macroalbuminuria.
Fig. 1 Effect of hyperglycaemia on the kidney. (DeFronzo et al. 2021)
Our Animal Models of Diabetic Nephropathy
- Nephrectomy/Streptozotocin (STZ)/High Fat Diet-Induced Diabetic Nephropathy (DN) Model
- Spontaneous Diabetic Nephropathy Model
Quotation and Ordering
Backed by a team of seasoned experts and equipped with a wealth of technical expertise, Creative Bioarray takes pride in providing an extensive array of services tailored to pharmacology and pharmacodynamic studies. Our commitment to excellence ensures that we offer the most comprehensive solutions in the industry, catering to the diverse needs of our clients. If you are interested in our services, please feel free to contact us at any time or submit an inquiry to us directly.
Reference
- DeFronzo, R.A., et al. Pathophysiology of diabetic kidney disease: impact of SGLT2 inhibitors. Nature Reviews Nephrology, 2021, 17(5): 319-334.
For research use only. Not for any other purpose.
