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Disease Models
- Oncology Models
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Inflammation & Autoimmune Disease Models
- Rheumatoid Arthritis Models
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- Multiple Sclerosis (MS) Models
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- Sjögren's Syndrome Model
- LPS-induced Acute Lung Injury Model
- Peritonitis Models
- Passive Cutaneous Anaphylaxis Model
- Delayed-Type Hypersensitivity (DTH) Models
- Inflammatory Bowel Disease Models
- Systemic Lupus Erythematosus Animal Models
- Asthma Model
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- Atopic Dermatitis (AD) Model
- Scleroderma Model
- Gouty Arthritis Model
- Carrageenan-Induced Air Pouch Synovitis Model
- Carrageenan-Induced Paw Edema Model
- Experimental Autoimmune Myasthenia Gravis (EAMG) Model
- Cardiovascular Disease Models
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Neurological Disease Models
- Alzheimer's Disease Modeling and Assays
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- Acute Spinal Cord Injury (ASCI) Model
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- Hypoxic-Ischemic Encephalopathy (HIE) Model
- Tourette Syndrome (TS) Model
- Amyotrophic Lateral Sclerosis (ALS) Model
- Huntington's Disease (HD) Model
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Urology Disease Models
- Cisplatin-induced Nephrotoxicity Model
- Unilateral Ureteral Obstruction Model
- 5/6 Nephrectomy Model
- Renal Ischemia-Reperfusion Injury (RIRI) Model
- Diabetic Nephropathy (DN) Models
- Passive Heymann Nephritis (PHN) Model
- Adenine-Induced Chronic Kidney Disease (CKD) Model
- Kidney Stone Model
- Doxorubicin-Induced Nephropathy Model
- Orthopedic Disease Models
- Ocular Disease Models
Radiotherapy-Related Disease Models
Creative Bioarray has pioneered the creation of an array of Radiotherapy-Related Disease Models, meticulously designed to facilitate the development of innovative drugs and therapeutic strategies aimed at combating the complications and toxicities inherent in the radiotherapy treatment of a broad spectrum of cancers. These models are instrumental in simulating the complex interplay between radiotherapy and the human physiological system, providing researchers with invaluable tools to explore and address the unmet needs in reducing the adverse effects of radiation treatment. By leveraging these sophisticated simulations, the pharmaceutical and medical research communities can advance their understanding and interventions, ultimately paving the way for safer and more effective cancer therapies.
Radiotherapy is employed in over 50% of cancer treatments, serving both curative and palliative functions. It utilizes ionizing radiation to precisely target and eradicate tumorous tissue. However, this treatment can also inflict damage on surrounding healthy tissue, resulting in toxic side effects. Radiation triggers a series of repair mechanisms in normal tissues, commencing with the DNA damage response, which encompasses programmed cell death pathways such as apoptosis, mitotic catastrophe, and cellular aging. Subsequently, a persistent cytokine cascade is activated, fostering inflammation and the abnormal accumulation of extracellular matrix (ECM) and collagen. These processes are primarily regulated by an imbalance of reactive oxygen and nitrogen species (ROS/RNS) and tissue hypoxia.
Fig. 1 General cellular and tissue responses over time following treatment with radiotherapy. (De et al. 2019)
Our Radiotherapy-Related Disease Models
Creative Bioarray, equipped with a team of seasoned experts and cutting-edge facilities, is dedicated to offering our clients an extensive array of disease models that authentically capture the intricacies of conditions associated with radiotherapy. Our radiotherapy-related disease models encompass:
Radiation-Induced Intestinal Injury Model
Radiation-Induced Dermatitis Model
Radiation-Induced Lung Injury (RILI) Model
Acute Radiation Syndrome (ARS) Model
Quotation and Ordering
Creative Bioarray is a renowned preclinical CRO specializing in providing exceptional in vivo pharmacology services. Our services are tailored to meet the various needs of our clients, ensuring the highest standards of quality and reliability during the preclinical research phase. If you are interested in our services, please feel free to contact us at any time or submit an inquiry to us directly.
References
- De, Ruysscher.D., et al. Radiotherapy toxicity. Nature Reviews Disease Primers, 2019, 5(1): 13.
- Barazzuol, L., et al. Prevention and treatment of radiotherapy‐induced side effects. Molecular oncology, 2020, 14(7): 1538-1554.
For research use only. Not for any other purpose.
