Animal Model of Hyperuricemia

Hyperuricaemia is a metabolic disease characterized by high levels of blood uric acid. Uric acid is an end product of purine metabolism and hyperuricaemia is caused by purine metabolic abnormalities. It has been indicated that hyperuricaemia is an important risk factor for gout, cardiovascular disease, hypertension, diabetes, and chronic kidney disease. In recent years, the prevalence of hyperuricemia in the world has gradually increased. However, its specific pathogenesis and targeting drugs still need further study.

Creative Bioarray, with a prestigious team in the industry, focuses on providing customized experiment services to help customers assess the efficacy of compounds and study the associated pathological mechanisms of hyperuricemia.

Hyperuricemia include but not limited to:

• Potassium Oxonate-induced Hyperuricaemia Model

Species available

• Rat
• Mouse

Our capabilities

• We analyze the level of uric acid using Ultra Performance Liquid Chromatography (UPLC).
• We evaluate the effect of test compounds on the histopathology of renel tissue by H&E staining.

Assays available

• Blood collection
• Decection of the level of uric acid
• Biochemical analysis
• Pathological evaluation

With extensive experience in the field of hyperuricemia, we are confident to help you overcome any upcoming challenges. Our experts are fully capable of customizing our protocols and assays to meet your specific needs. With our help, we wish to facilitate your research with high efficiency.

Study examples

Figure. 1. Effect of Dioscin on the histopathology of renal tissue in hyperuricemia mice . A: Histopathological analysis of renal tissues after induced by using adenine and PO (HE, ×400); B: Phenotype of kidney in hyperuricemia mice; N: Normal rat; M: Adenine and PO induced hyperuricemia mice; Ben: Adenine and PO induced hyperuricemia mice with Probenecid 50 mg/kg/day (p.o.); Dioscin: PO induced hyperuricemia rat with Dioscin in different dosage; Δ: mixed cellular infiltrate in the tubules; О: corpora amylacea; □: tubular ectasia.

Quotation and ordering

If you have any special needs or questions regarding our services, please feel free to contact us. We look forward to cooperating with you in the future.

Reference

1. Zhang Y , Jin L , Liu J , et al. Effect and mechanism of dioscin from Dioscorea spongiosa on uric acid excretion in animal model of hyperuricemia[J]. Journal of Ethnopharmacology, 2017, 214:29.

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For research use only. Not for any other purpose.