Capsaicin-Induced Inflammatory Pain Model
To rigorously evaluate the efficacy of analgesics, Creative Bioarray has meticulously established the capsaicin-induced inflammatory pain model. Our commitment to excellence is evident in the stringent protocols we follow and the cutting-edge technology we employ. By choosing Creative Bioarray, you are partnering with a team of experts who are dedicated to providing you with reliable data and actionable insights.
Capsaicin, the potent irritant compound found in chili peppers of the genus Capsicum, is renowned for its culinary applications but also plays a significant role in scientific research. Beyond its flavor-enhancing properties, capsaicin serves as a valuable tool in both preclinical and clinical studies, offering insights into the mechanisms of thermal pain. When applied, capsaicin triggers nociceptors, leading to neurogenic inflammation through the activation of TRPV1 channels. This activation can manifest as hyperalgesia, allodynia, and flare reactions when capsaicin is injected intradermally in rats. These responses are critical for researchers to study the complex interplay between nociceptive pathways and the body's inflammatory response, aiding in the development of targeted pain management therapies.
Our Capsaicin-Induced Inflammatory Pain Model
- Available Animal
- Rat
- Mouse
- Modeling Method
Administration of capsaicin into rat/mouse plantar surface can induce inflammatory pain.
- Endpoints
- Behavioral tests: Von Frey test, Hot plate test, etc
- Cytokine analysis
- qPCR or Western blot
- Histology analysis
- Other customized endpoints
In addition, we also provide other inflammatory pain models that maybe you are interested in:
- Formalin-Induced Inflammatory Pain Model
- Complete Freund's Adjuvant (CFA)-Induced Inflammatory Pain Model
- Carrageenan-Induced Inflammatory Pain Model
Quotation and Ordering
Creative Bioarray boasts extensive expertise in conducting in vivo efficacy studies. By leveraging our comprehensive experience, our clients can obtain robust and reliable results across a wide range of biological and pharmaceutical applications. If you are interested in our services, please feel free to contact us at any time or submit an inquiry to us directly.
