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Doxorubicin-Induced Nephropathy Model
With extensive expertise in urology disease model establishment, Creative Bioarray offers a doxorubicin-induced nephropathy model to clients worldwide. This model is designed to facilitate the evaluation of potential novel therapeutics and to elucidate the underlying mechanisms of nephropathy. By utilizing doxorubicin to induce nephropathy, researchers can closely mimic the human condition, providing valuable insights into disease pathophysiology and enabling the development of more effective treatments.
Doxorubicin (DOX), also known as Adriamycin, is a widely used chemotherapeutic drug. However, its clinical utility is limited due to its harmful effects on various organs, particularly the kidneys. Adriamycin nephropathy, a rodent model of chronic kidney disease (CKD), closely mirrors human primary focal segmental glomerulosclerosis (FSGS). This model is characterized by podocyte injury, followed by glomerulosclerosis, tubulointerstitial inflammation, and fibrosis. These features make it an attractive system for in vivo drug screening, allowing researchers to study the mechanisms of kidney damage and evaluate the efficacy of potential therapeutic agents in a setting that closely resembles human disease.
Our Doxorubicin-Induced Nephropathy Model
- Available Animal
- Rat
- Mouse
- Modeling Method
Creative Bioarray has developed a nephropathy model induced by tail vein injection of doxorubicin. This model is designed to closely mimic the human condition, providing researchers with a reliable platform to study the mechanisms of nephropathy and evaluate potential therapeutic agents.
- Endpoints
- Biochemical parameters analysis: blood urea nitrogen (BUN), creatinine, urine protein
- Body weight
- Kidney weight
- Histology analysis
- qPCR or Western Blot
- Other customized endpoints
Example Data
Fig. 1 GL-PP alleviates DOX-induced proteinuria and renal dysfunction in mice. (A) Temporal progression of proteinuria. (B) Change in body weight over the course of the experiment. (C) Blood urea nitrogen. (D) Blood creatinine. (E) Plasma triglycerides. (F) Representative image of renal PAS staining. (G) Semi-quantitative scoring of glomerular injury. (H) Semi-quantitative scoring of tubulointerstitial injury. (Fang et al. 2023)
Quotation and Ordering
Creative Bioarray is committed to delivering fast and comprehensive services of the highest quality to expedite drug discovery. If you have any special needs or questions regarding our services, please feel free to contact us at any time or submit an inquiry directly to us.
Reference
- Fang, H., et al. Therapeutic potential of Ganoderma lucidum polysaccharide peptide in Doxorubicin-induced nephropathy: modulation of renin-angiotensin system and proteinuria Frontiers in Pharmacology, 2023, 14: 1287908.
For research use only. Not for any other purpose.
