3D Spheroid Tumor Cell Panel Screening

Creative Bioarray's 3D spheroid tumor cell panel screening service offers a sophisticated approach for investigational cancer therapies by utilizing 3D spheroids derived from a diverse panel of distinct cell lines representing different tumor types.

Figure 1. Over 500 human tumor cell lines available in our cancer cell bank.

This innovative methodology allows researchers to evaluate the therapeutic efficacy and tumor-penetrating capability of new anti-cancer compounds in a more clinically relevant environment, as 3D spheroids closely mimic the in vivo tumor architecture compared to traditional 2D cell cultures. Traditional 2D cell culture can fail to replicate the complex tumor microenvironment, affecting cellular behavior, drug response, and overall therapeutic efficacy. In contrast, 3D spheroids maintain better cell-to-cell and cell-to-matrix interactions, mimicking the in vivo situation more closely.

By screening compounds against this extensive panel, scientists can efficiently determine the efficacy of novel therapies across a wide variety of cancer types. This service not only accelerates the drug discovery process but also helps identify potential responders or resistant cancer types, ultimately leading to more personalized treatment strategies.

3D Spheroid Tumor Cell Panels

• Pre-configured panels: Five to 42 pre-validated 3D spheroid tumor models can be selected.
  5 Model Panel (One indication)
  30 Model Panel (across solid tumor indications)
  42 Model Panel (across solid tumor indications)
• Custom Panels: Clients select specific cell lines of interest from our cell bank to create a tailored cell panel for screening.

Highlights

• More Effective Modeling of Tumor Behavior

3D spheroids more closely resemble the in vivo tumor microenvironment, including cellular architecture, extracellular matrix (ECM) interactions, and spatial organization. This results in more physiologically relevant responses to drug treatments.

• Improve the Efficiency of Drug Research and Development

Drug responses were evaluated using 3D models across multiple cell lines to better understand the effectiveness of compounds and to prioritize the most appropriate and effective compounds before conducting in vivo studies.

• Standardized, High throughput Screening Process

Cell viability was measured using the 3D CellTiter-Glo® assay for accurate IC50/GI50 assays. Extensive analyses including colony formation, cell cycle analysis and apoptosis studies were performed.

• Personalized Expert Consultation

Get customized guidance from our specialists to identify the ideal cell lines and panels for your research needs.

Application

• New Molecular Drug Development
• New Biomarker Discovery
• Exploring Innovative Therapeutic Approaches: Combining new medications with FDA-approved drugs and chemotherapy.

Explore Other Options

• 3D Spheroid & Organoid Culture Reagents
• 3D Spheroid Platform for Drug Development

• 3D Tumor Spheroid Assay

For research use only. Not for any other purpose.