Syngeneic Tumor Model-based Drug Screening

Syngeneic Tumor Model

Immunotherapy is a type of cancer treatment that boosts the body's natural defenses to fight the cancer. It uses substances made by the body or in a laboratory to improve or restore immune system function. Immuno-Oncology is a type of immunotherapy that has the specific purpose of treating cancer, which is sweeping through all levels of oncology research, from academia to biotech and pharma. With the growing interest in exploring immunotherapy and immune-oncology for cancer, the use of xenograft models in immunocompromised animals presents challenges. A more effective approach is the use of syngeneic mouse models.

Syngeneic tumor models are allografts derived from immortalized mouse cancer cell lines which originated from the same inbred strain of mice. The models are critical to novel immuno-based therapy development, by providing a valuable system for assessing new single agent and allowing us to study how cancer therapies perform in conjunction with a functional immune system.

With advanced research platforms and exquisite technical team, Creative Bioarray offers a broad range of syngeneic tumor models in multiple formats and dedicates in assisting our customers with their experimental project to accelerate their studies. Using our syngeneic mouse models, customers can interrogate novel immune treatments and combination therapies.

Advantages

Serve as surrogates for human patients
Availability and low cost of host animals
Recipient mice have normal, competent immune systems
Fast turned around time
Ease of model validation and setup
Reproducibility of data

Generation of syngeneic tumor model

Syngeneic Tumor Model

Applications

Immuno-based therapy development
Therapeutic effect evaluation
Drug development

Study examples

By using syngeneic tumor models, researchers have proved that the hTERT promoter induced tumor-specific Bax gene expression and suppressed syngeneic tumor growth in immune-competent mice with no obvious acute or long-term toxic effects, sequentially demonstrated that the hTERT promoter may allow the use of proapoptotic genes for cancer treatment without noticeable effects on progenitor cells.

Syngeneic Tumor Model

Fig. 1 Suppression of syngenic tumor growth by hTERT promoterinduced and tumor-specific Bax gene expession

Quotation and ordering

If you have any special needs in establishment or application of syngeneic tumor model, please contact us for this special service. Let us know what you need and we will accommodate you. We look forward to working with you in the future.

References

1.	Mosely S.I.S.; et al. Rational selection of syngeneic preclinical tumor models for immunotherapeutic drug discovery. Cancer Immunology Research. 2017, 5(1): 29-41.
2.	Gu J.; et al. hTERT promoter induces tumor-specific Bax gene expression and cell killing in syngenic mouse tumor model and prevents systemic toxicity. Gene Therapy. 2002, 9: 30-37.

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For research use only. Not for any other purpose.