Cough Models

With an extensive background in respiratory diseases, Creative Bioarray has meticulously honed its capabilities in establishing reliable and reproducible animal models for coughing. Our cough animal models provide a comprehensive platform for drug discovery and development. By leveraging these models, clients can gain valuable insights into the pharmacodynamics, pharmacokinetics, and overall efficacy of their candidate drugs.

Cough, as a crucial airway reflex, serves to safeguard the airways and lungs from aspirate, inhaled irritants, and accumulated secretions. It is also a prevalent symptom that prompts patients to seek medical attention. However, cough can be complicated by various issues such as reflux, incontinence, insomnia, and a decline in overall quality of life. Despite extensive research on the effectiveness of antitussive compounds in animal models, which have yielded promising results, the treatment of pathological cough in humans remains inadequate. Hence, the development of reliable animal models of cough is imperative to further advance our understanding and treatment of this condition.

Our Animal Models of Cough

With years of experience in respiratory diseases, Creative Bioarray has established stable cough animal models for our clients to evaluate the efficacy of their drug candidates. Details are as follows.

Available Animal

Mouse
Guinea pig

Modeling Method

Ammonia Water-Induced Cough Model (Mouse)
Citric Acid-Induced Cough Model (Guinea pig)
Capsaicin-Induced Cough Model (Guinea pig)

Endpoints

Cough number
H&E staining: lung
Cytokine analysis: lung
Body weight
qPCR or Western blot
Other customized endpoints: available upon request

Quotation and Ordering

Creative Bioarray, as a leading CRO partner, provides various disease models for our clients to accurately evaluate the potential efficacy of their drug candidates in a controlled and scientifically rigorous environment. We work closely with clients to understand their specific research objectives and tailor our services to meet their unique needs. If you are interested in our services, please feel free to contact us at any time or submit an inquiry to us directly.

Reference

Plevkova, J., et al. Animal models of cough. Respiratory Physiology & Neurobiology, 2021, 290: 103656.

For research use only. Not for any other purpose.