Inflammatory Pain Models

Creative Bioarray offers a comprehensive suite of high-quality inflammatory pain models, tailored to meet the diverse needs of clients globally. These models serve as invaluable tools for evaluating the efficacy of innovative therapeutic agents, enabling researchers to gain deeper insights into the mechanisms underlying inflammatory pain and to develop more effective treatments. With our expertise in the field and commitment to quality, we strive to support our clients in their quest for groundbreaking discoveries in pain management.

The inflammatory response is a finely tuned series of physiological events that are initiated in response to injury or infection, with the objective of combating and resolving the underlying pathology. This response is manifested through five hallmark symptoms: redness (rubor), heat (calor), swelling (tumor), pain or hypersensitivity (dolor), and loss of function (functio lasea). Typically, inflammation serves as a critical protective mechanism that is indispensable for the process of wound healing. However, during acute inflammation, significant pain is generated due to the direct activation of sensory neurons, which are responsible for conveying pain signals.

To study the mechanisms of persistent pain triggered by tissue injury, animal models of inflammatory pain have been extensively utilized. Researchers employ a wide range of inflammatory agents and irritants, such as complete Freund's adjuvant, carrageenan, and capsaicin, among others, to induce tissue damage and hyperalgesia. These models provide valuable insights into the complex interplay of factors that contribute to the development and maintenance of inflammatory pain, facilitating the discovery of potential therapeutic targets for pain management.

Schematic diagram illustrating the underlying mechanisms involved in the onset and continuation of inflammatory pain, highlighting the various pathways and factors contributing to this condition. Fig. 1 Mechanisms for the initiation and maintenance of inflammatory pain. (Vasko 2009)

Our Animal Models of Inflammatory Pain

Creative Bioarray offers a comprehensive range of inflammatory pain models that cover the spectrum from acute inflammatory pain to chronic pain conditions. These models are designed to mimic various types of inflammatory pain that can be caused by different factors, such as injury, infection, or autoimmune diseases. By using these models, researchers can study the mechanisms of inflammatory pain and test the efficacy of potential therapeutic agents. The inflammatory pain models provided by Creative Bioarray include:

Quotation and Ordering

Creative Bioarray boasts a diverse range of high-quality disease models tailored to meet our clients' needs. Leveraging our extensive experience in the field of animal modeling and superior professional capabilities, our scientists are committed to assisting you in selecting the most suitable rodent models for your research. If you are interested in our services, please feel free to contact us at any time or submit an inquiry to us directly.

Reference

Vasko, M.R. Inflammatory Pain. Encyclopedia of Neuroscience, 2009.

For research use only. Not for any other purpose.