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- Cardiovascular Disease Models
- Drug-induced Heart Failure Model
- Doxorubicin-induced Heart Failure Model
Services
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Cell Services
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Cell Line Testing and Assays
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Stem Cell Research
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iPSC Differentiation
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ISH/FISH Services
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FISH Applications
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In Vivo DMPK Services
- Pharmacokinetic and Toxicokinetic
- PK/PD Biomarker Analysis
- Bioavailability and Bioequivalence
- Bioanalytical Package
- Metabolite Profiling and Identification
- In Vivo Toxicity Study
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- Quantitative Tissue Distribution
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Doxorubicin-induced Heart Failure Model
Doxorubicin (DOX), an anthracycline compound, is commonly used in the therapy of various tumors. At the same time, DOX promotes the production of reactive oxygen species (ROS), DNA mutagenesis, cell membrane damage and the release of inflammatory factors in the heart of tumor patients, and eventually lead to irreversible cardiomyopathy and heart failure. To date, Doxorubicin-induced heart failure has been a widely used model characterized by left ventricular dilatation and loss of systolic function.
Creative Bioarray specializes in providing customized pharmacodynamic research services to help customers explore the potential cardioprotective drugs and study the pathological mechanisms of cardiomyopathy and heart failure by this model.
Species available
- Mouse
- Rat
Our Capabilities
- We detect changes in myocardial morphologyby H&E staining and so on.
- We evaluate myocardial ultrastructure by TEM.
Assays available
- Echocardiography
- Transmission Electron Microscope (TEM)
- Histopathological evaluation
- Biochemical analysis
With extensive experience in the field of cardiovascular diseases, we are confident to help you overcome any upcoming challenges. Our experts are fully capable of customizing our protocols and assays to meet your specific needs. With our help, we wish to facilitate your research with high efficiency.
Study examples
Figure. 1. H&E-stained cardiac tissue.
Figure. 2. Representative TEM images of cardiac tissue (scale bar, 1 μm). Red arrows, mitochondria; blue arrows, myofibrils.
Quotation and ordering
If you have any special needs or questions regarding our services, please feel free to contact us. We look forward to cooperating with you in the future.
Reference
Li, Xueping, et al. "Lingguizhugan decoction attenuates doxorubicin-induced heart failure in rats by improving TT-SR microstructural remodeling." BMC Complementary and Alternative Medicine 19.1 (2019): 1-11.
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For research use only. Not for any other purpose.
