- You are here: Home
- Disease Models
- Liver Disease Models
Disease Models
- Oncology Models
-
Inflammation & Autoimmune Disease Models
- Rheumatoid Arthritis Models
- Glomerulonephritis Models
- Multiple Sclerosis (MS) Models
- Ocular Inflammation Models
- Sjögren's Syndrome Model
- LPS-induced Acute Lung Injury Model
- Peritonitis Models
- Passive Cutaneous Anaphylaxis Model
- Delayed-Type Hypersensitivity (DTH) Models
- Inflammatory Bowel Disease Models
- Systemic Lupus Erythematosus Animal Models
- Asthma Model
- Sepsis Model
- Psoriasis Model
- Atopic Dermatitis (AD) Model
- Scleroderma Model
- Gouty Arthritis Model
- Carrageenan-Induced Air Pouch Synovitis Model
- Carrageenan-Induced Paw Edema Model
- Experimental Autoimmune Myasthenia Gravis (EAMG) Model
- Cardiovascular Disease Models
-
Neurological Disease Models
- Alzheimer's Disease Modeling and Assays
- Seizure Models
- Parkinson's Disease Models
- Ischemic Stroke Models
- Acute Spinal Cord Injury (ASCI) Model
- Traumatic Brain Injury (TBI) Model
- Hypoxic-Ischemic Encephalopathy (HIE) Model
- Tourette Syndrome (TS) Model
- Amyotrophic Lateral Sclerosis (ALS) Model
- Huntington's Disease (HD) Model
- Intracerebral hemorrhage (ICH) Models
- Pain Models
- Metabolic Disease Models
- Liver Disease Models
- Rare Disease Models
- Respiratory Disease Models
- Digestive Disease Models
-
Urology Disease Models
- Cisplatin-induced Nephrotoxicity Model
- Unilateral Ureteral Obstruction Model
- 5/6 Nephrectomy Model
- Renal Ischemia-Reperfusion Injury (RIRI) Model
- Diabetic Nephropathy (DN) Models
- Passive Heymann Nephritis (PHN) Model
- Adenine-Induced Chronic Kidney Disease (CKD) Model
- Kidney Stone Model
- Doxorubicin-Induced Nephropathy Model
- Orthopedic Disease Models
- Ocular Disease Models
Liver Disease Models
Liver diseases occur frequently and are life-threatening for humans. The underlying causes vary from viral infections, autoimmune diseases and intoxications (including alcohol abuse) to unbalanced diets. Although the liver can regenerate without injury in the early stages of the disease, it cannot heal in the later stages and may require an organ transplant. We must understand the underlying mechanisms in order to design and develop new drugs in this area. Mature and stable animal models to mimic human liver diseases could thus play an important role.
Creative Bioarray established a variety of animal models for liver diseases, including acute liver injury, chronic liver injury, chronic fatty liver disease, alcoholic steatohepatitis (ASH) and nonalcoholic steatohepatitis (NASH). These models have unique characteristics and etiologies of human liver diseases to help clients assess the efficacy of new compounds in related clinical liver diseases and better understand the underlying mechanisms of new drugs.
Our portfolio of liver disease models covers:
- Alcoholic liver disease model
- Liver fibrosis model
- Acute liver injury
- Chronic liver injury
- Chronic fatty liver disease
- Alcoholic steatohepatitis (ASH) & non-Alcoholic steatohepatitis (NASH)
We support R&D of new compounds, with various endpoints
- Physical observation and examination
- Biomarker analysis
PCR, ELISA, Western Blot, Serum ALT/AST analysis
- Histology analysis
H&E staining, Masson staining, Sirius red staining
Data & Figures
Figure.1 HE and masson staining of NASH model
Quotation and ordering
We have extensive experience in developing disease models based on scientific publications. To discuss any of these models further or to discuss the possibility of developing alternative models, please do not hesitate to contact us.
Reference
- Liu, Y. et al. Animal models of chronic liver diseases. Am. J. Physiol. Gastrointest. Liver Physiol. 304, G449-468 (2013).
For research use only. Not for any other purpose.
