- You are here: Home
- Disease Models
- Urology Disease Models
- Unilateral Ureteral Obstruction Model
Disease Models
- Oncology Models
-
Inflammation & Autoimmune Disease Models
- Rheumatoid Arthritis Models
- Glomerulonephritis Models
- Multiple Sclerosis (MS) Models
- Ocular Inflammation Models
- Sjögren's Syndrome Model
- LPS-induced Acute Lung Injury Model
- Peritonitis Models
- Passive Cutaneous Anaphylaxis Model
- Delayed-Type Hypersensitivity (DTH) Models
- Inflammatory Bowel Disease Models
- Systemic Lupus Erythematosus Animal Models
- Asthma Model
- Sepsis Model
- Psoriasis Model
- Atopic Dermatitis (AD) Model
- Scleroderma Model
- Gouty Arthritis Model
- Carrageenan-Induced Air Pouch Synovitis Model
- Carrageenan-Induced Paw Edema Model
- Experimental Autoimmune Myasthenia Gravis (EAMG) Model
- Cardiovascular Disease Models
-
Neurological Disease Models
- Alzheimer's Disease Modeling and Assays
- Seizure Models
- Parkinson's Disease Models
- Ischemic Stroke Models
- Acute Spinal Cord Injury (ASCI) Model
- Traumatic Brain Injury (TBI) Model
- Hypoxic-Ischemic Encephalopathy (HIE) Model
- Tourette Syndrome (TS) Model
- Amyotrophic Lateral Sclerosis (ALS) Model
- Huntington's Disease (HD) Model
- Intracerebral hemorrhage (ICH) Models
- Pain Models
- Metabolic Disease Models
- Liver Disease Models
- Rare Disease Models
- Respiratory Disease Models
- Digestive Disease Models
-
Urology Disease Models
- Cisplatin-induced Nephrotoxicity Model
- Unilateral Ureteral Obstruction Model
- 5/6 Nephrectomy Model
- Renal Ischemia-Reperfusion Injury (RIRI) Model
- Diabetic Nephropathy (DN) Models
- Passive Heymann Nephritis (PHN) Model
- Adenine-Induced Chronic Kidney Disease (CKD) Model
- Kidney Stone Model
- Doxorubicin-Induced Nephropathy Model
- Orthopedic Disease Models
- Ocular Disease Models
Unilateral Ureteral Obstruction Model
The Unilateral Ureteral Obstruction (UUO) model is widely used to induce acute kidney injury, where the primary feature of UUO is tubular injury as a result of obstructed urine flow. The experimental procedure involves ligation of the ureter, usually with a silk thread, most commonly of the left one. The kidney of the ligated ureter is termed the "Obstructed Kidney". Creative Bioarray provides you the UUO model for studying the mechanism of acute kidney injury and developing related therapeutic drugs.
Application and advantages
The UUO model has been used by some researchers and shows significant research potential. With this model, you can apply your research to the following aspects:
- Explore the resolution of kidney inflammation together with key aspects of tissue repair.
- Reveal useful biomarkers of progression of renal disease and new therapies.
- Study the pathogenesis of renal fibrosis and drug intervention.
Besides, it is one of the most common models of urology disease. The reason is that it is easily induced in rodents, with high reproducibility and a short timeline. This makes it successfully applied in the above aspects.
Related Assays provided by Creative Bioarray including
- Clinical observations
- Microalbumin test
- Biochemical analysis
- RT-PCR & western blot
- Histology & immunohistochemistry
Data & Figures
Figure 1. (A) Representative H&E staining of kidney sections under 50× and 200× magnification. (B) Tubulointerstitial injury score of the four groups.
Other urological disease models are also available:
Quotation and ordering
For more details, please do not hesitate to contact us.
Reference
Gu L et al. Ribes diacanthum Pall (RDP) ameliorates UUO-induced renal fibrosis via both canonical and non-canonical TGF-beta signaling pathways in mice. J. Ethnopharmacol., 2018, 231:302-310.
For research use only. Not for any other purpose.
