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- Cisplatin-induced Nephrotoxicity Model
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Cisplatin-induced Nephrotoxicity Model
Cisplatin (cis-diamminedichloroplatinum II; CP) is used widely as an antitumor drug in the treatment of cancer. But this compound is accompanied with renal toxicity, which is a major clinical concern. To help understand mechanisms involved in the development of kidney injury, cisplatin-induced nephrotoxicity model has been developed by researchers. Cisplatin-induced nephrotoxicity model is essential in the investigation of underlying mechanisms of acute kidney injury. This model is well appreciated and widely used due to its simplicity. Creative Bioarray uses the cisplatin-induced nephrotoxicity model for studying the mechanism of cute kidney injury and developing related therapeutic drugs.
Application and advantages
Cisplatin is the most commonly used chemotherapy drug. Due to its nephrotoxicity, cisplatin-induced nephrotoxicity model is considered an ideal model for studying the early pathophysiological features of acute nephrotoxicity. With this model, you can apply your research to the following aspects:
- Study the mechanism by which statins protect against nephrotoxicity.
- Develop new compounds to protect against nephrotoxicity of cisplatin.
- Understand the cellular and molecular mechanisms of nephrotoxicity.
Available Assays provided by Creative Bioarray including
- Clinical observations
- Kidney weight
- Biochemical parameter analysis
- Serum levels examination
- Histology & immunohistochemistry
Data & Figures
Fig. 1. RDP treatment attenuated the renal histological changes induced by cisplatin in mice: (a) control group; (b) RDP alone group; (c) cisplatin-injected group; (d) RDP plus cisplatin group. Arrows show damaged tubular cells, stars show intratubular cast formation. H&E staining. Magnification 200X. Tubular score (e). Each data points represent mean±S.E.M.
Other urological disease models are also available:
Quotation and ordering
For more details, please do not hesitate to contact us.
Reference
Tilyek A et al. The protective effects of Ribes diacanthum Pall on cisplatin-induced nephrotoxicity in mice. Journal of Ethnopharmacology, 2016, 178:297-306.
For research use only. Not for any other purpose.
