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- 5/6 Nephrectomy Model
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5/6 Nephrectomy Model
Chronic kidney injury is a great risk factor for urology disease events and mortality. 5/6 nephrectomy model represents one of the most used animal models of chronic kidney injury in rodents. The reduction of renal mass is performed by either infarction or surgical excision of both poles, with removal of the contralateral kidney. It enables to investigate the effects of pharmacological, nutritive and other factors on functional and morphological renal parameters.
Application and advantages
Development of disease models could contribute to a better understanding of chronic kidney injury. Among the available disease models for chronic kidney injury, the 5/6 nephrectomy model has been a mainstay of studies of progressive renal disease. The remarkable features of 5/6 nephrectomy model in mice are common to chronic kidney injury observed in humans. Therefore, it has been used to test new therapies and develop related therapeutic drugs.
Figure 1. The procedure of 5/6 nephrectomy model.
Available Assays provided by Creative Bioarray include
- Clinical observations
body and remnant kidney weight, chow and water intake, 24 h urine volume - Renal morphometry and histological analysis
- Biochemical parameter analysis
- Plasma and urine analysis
- Hemodynamic measurements
Data & Figures
Figure 2. Kidney morphology. (a) Renal interstitial fibrosis, (b) typical photomicrographs of the kidneys stained with sirius red for interstitial fibrosis.
Other urological disease models are also available:
Quotation and ordering
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Reference
Tsuprykov O et al. The dipeptidyl peptidase inhibitor linagliptin and the angiotensin II receptor blocker telmisartan show renal benefit by different pathways in rats with 5/6 nephrectomy. Kidney International, 2016, 89(5):1049-1061.
For research use only. Not for any other purpose.
