In vitro Full Thickness Skin Model

Compared to animal experiments or the use of ex vivo skin, in vitro 3D Full Thickness Skin Model (Human Skin Equivalent, FTSK, HSE) used under defined test conditions offer several advantages: i) since most models are composed of primary human cells, inter-species extrapolation is avoided; ii) in contrast to ex vivo human skin, repeated application of formulations can be performed for at least several weeks; iii) work with the ready to use epidermal FTSK (HSE) does not require advanced knowledge of cell culture techniques; iv) the employment of FTSK (HSE) leads to the reduction of laboratory animal use in regulatory toxicology as well as in preclinical studies.

Creative Bioarray provides in vitro Full Thickness Skin Model (Human Skin Equivalent, FTSK, HSE) to our customers for developing innovative skin care products, and to cosmetic scientists for evaluating novel ingredients and formulations.

Creative Bioarray Reconstructed FTSK (HSE) are composed of a dermal compartment containing human skin fibroblasts embedded in a collagen matrix and human keratinocytes seeded on top to form the epidermis.