In vitro Reconstructed Human Epidermis (RHE)

In vitro 3D reconstructed human epidermis from normal human keratinocytes cultured on an inert polycarbonate filter at the air-liquid interface, in a chemically defined medium. This model exists at different stages of maturity. The Creative Bioarray Reconstructed Human Epidermis Model (RHE) is very similar to human skin in terms of morphology, of differentiation markers and of functional characteristics.

Fig.1 Representative histology for 3D culture raised to air-liquid interface, structures are histologically similar to in vivo human epidermis.

Specific Markers

• Filaggrin
• Involucrin
• Loricrin
• corneodesmosin
• Keratin 10
• Keratin 5
• Presence of different epidermal classes of lipids comprising ceramides
• Type IV collagen
• Laminin V
• Alpha6Beta4-integrin
• BP antigen
• Ki67
• Others

Fig.2 Epidermal differentiation and dermal matrix markers by Native Skin and in vitro RHE model

Applications

Creative Bioarray Reconstructed Human Epidermis Model (RHE) is cultured at the air-liquid interface and allows for the evaluation of topically applied compounds, chemicals, cosmetic/personal care product ingredients and final formulations.

• Skin barrier function and hydration
• Skin irritation
• Skin corrosion
• UV exposure
• DNA damage
• Bacterial adhesion
• Omics
• Permeability

Quote and ordering

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For research use only. Not for any other purpose.