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- Oxazolone-Induced Atopic Dermatitis (AD) Model
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Oxazolone-Induced Atopic Dermatitis (AD) Model
Creative Bioarray provides a stable atopic dermatitis (AD) model induced by oxazolone for novel drug discovery and development. Our scientific team has extensive experience helping our clients with the selection of appropriate models and assays, as well as obtaining reliable and accurate results to accelerate the development process of your drugs.
Atopic dermatitis (AD) is a chronic inflammatory skin condition that recurs frequently, resulting from intricate interactions among genetic predisposition, environmental factors, immune dysregulation, and skin barrier dysfunction. Given its complexity, researchers have sought to replicate its symptoms in animal models to gain a deeper understanding of the disease. One such well-established model is the mouse model with oxazolone-induced AD-like skin manifestations. This model is induced through repeated epicutaneous administrations of oxazolone, a powerful hapten capable of eliciting a chronic Th2 hypersensitivity response that closely mimics the initial features observed in human AD. Through this model, we can investigate the pathogenesis of AD and potentially develop more effective therapeutic strategies.
Our Oxazolone-Induced Atopic Dermatitis (AD) Model
- Available Animal
Mouse - Modeling Method
Step 1: In the sensitization phase, mice are sensitized with oxazolone or vehicle applied to the shaved dorsal skin and ear.
Step 2: In the challenge phase, mice are repeatedly challenged with oxazolone or vehicle applied to the shaved dorsal skin and ear. - Endpoints
- Body weight
- Ear thickness
- Serum analysis: total IgE, TNF-α, etc.
- H&E staining
- Other customized endpoints: available upon request
Example Data
Fig. 1 (A) Ear thickness of mouse. (B) Ear morphology of mouse.
Fig. 2 Histological examination confirmed that epidermal and dermal thickness were increased with dermal inflammatory cell infiltration in the AD+1649b group compared to the AD group (H&E, Scale bar=100 μm).
In addition, we also provide other AD models that maybe you are interested in:
- 2,4-dinitrofluorobenzene (DNBF)-Induced Atopic Dermatitis (AD) Model
- Calcipotriol (MC903)-Induced Atopic Dermatitis (AD) Model
Quotation and Ordering
Creative Bioarray is happy to share our cutting-edge technology and extensive expertise in rodent disease models to facilitate our clients' research and project development. If you are interested in our service, please feel free to contact us at any time or submit an inquiry to us directly.
Reference
- Bae, Y.J., et al. Effects of particulate matter in a mouse model of oxazolone-induced atopic dermatitis. Annals of Dermatology, 2020, 32(6): 496.
For research use only. Not for any other purpose.
