Endocrine Disruption Screening Assay

Endocrine Disrupting Chemicals (EDCs) are exogenous chemical substances that interfere with the endocrine systems of humans and animals, potentially causing adverse effects on reproduction, development, metabolism, and brain function. EDCs include natural oestrogens, phytoestrogens, fungi oestrogens, synthetic oestrogens and other pollutants in the environment. Examples are Bisphenol A (BPA) and Nonylphenol, ubiquitous in plastics, pesticides, household items and the environment. These substances are also able to accumulate easily and can persist for many years, so that they are impossible to detoxify after they've made their way up the food chain. EDCs can enter the atmosphere via various sources such as incineration, industrial waste, and pesticide emissions, then accumulate in air, water, soil and living organisms, where they end up as ubiquitous contaminants, posing a serious risk. They are highly studied in the causes of infertility, cancer and diabetes.

The scientific and regulatory communities have recently increased attention to the risks of such chemicals, calling for their sources to be controlled and monitored. Creative Bioarray provides the specialized "Endocrine Disruption Screening Assay" service to assist clients in properly diagnosing and evaluating endocrine disruption risks. The service focuses on evaluations of chemical influences on the endocrine system through high-throughput screening and bioinformatics data, including chemicals, pharmaceuticals, and environmental contaminants. We use OECD-standardized in vitro and in vivo assays to make the data credible and scientifically valid, supporting our customers' research and development decisions.

According to the revised framework by the OECD, endocrine disruption assessment is categorized into five levels:

Level 1 testing primarily involves reviewing existing data and non-testing information to preliminarily determine a chemical's potential as an endocrine disruptor.
Level 2 testing offers direct insights into a chemical's effects on specific endocrine receptors through in vitro assays.
Level 3 testing is in vivo studies in animal models to understand how chemicals impact endocrine mechanisms or pathways.
Level 4 testing is in vivo evaluations in animal models, assessing adverse effects on endocrine-related endpoints, such as reproductive and developmental abnormalities.
Level 5 testing is lifetime studies in animal models to provide comprehensive data on how chemicals affect endocrine systems across different life stages.

Creative Bioarray Offers a Comprehensive Endocrine Disruption Screening Assay, Including but not Limited to:

In vitro tests:

Estrogen Receptor (ER) Transactivation

Androgen Receptor (AR) Transactivation

Androgen Receptor (AR) Modulation

Estrogen Receptor-alpha (ER-α) Binding

Estrogen Receptor beta (ER-β) Binding

Androgen Receptor (AR) Binding

Steroidogenesis

Aromatase Assay

In vivo tests:

Short-term fish reproduction assays

Amphibian metamorphosis assays

Uterotrophic assays in rodents

Hershberger assays in rats

Peri-pubertal male and female assays

Repeated-dose toxicity studies

Two-generation reproductive toxicity studies

Extended one-generation reproductive toxicity studies

Service Features:

Creative Bioarray assembles a dedicated expert team around your endocrine disruption testing needs to create a specialized plan.
We possess a complete set of in vitro and in vivo testing systems, delivering economically efficient and rigorously scientific characterizations of substances' endocrine disruption potential.
Our endocrine disruption screening assay strictly complies with OECD and EPA guidelines, ensuring international recognition and comparability of results.

FAQ

1. What are Endocrine Disruptors?

Endocrine Disruptors (EDCs), also known as environmental hormones, are chemicals that interfere with the normal functions of the endocrine system. They are present in the environment and can disrupt every aspect of endocrine regulation, leading to abnormal effects. Common EDCs include various organic compounds, heavy metals, and certain hormones, as well as plastic stabilizers and pesticides.

2. Why conduct Endocrine Disruption Screening?

EDCs can cause significant disruptions, altering cellular, organ, and physiological functions, adversely affecting human health. Screening helps identify and mitigate these potential threats, guiding manufacturers towards safer alternatives and minimizing environmental impact.

3. What happens if a substance is identified as an endocrine disruptor?

Upon positive initial screening, further advanced risk assessment tests are recommended to elucidate the mechanisms and potential health impacts, along with risk management advisories.

4. How long does endocrine disruptor screening typically take?

The duration depends on test complexity and analysis depth, typically ranging from several weeks to months. We strive to offer the swiftest turnaround without compromising quality.

Quotation and Ordering

Backed by a team of experts with extensive experience, we assure you of top-quality data and tailored outcomes to satisfy your project needs. For any additional requirements or inquiries, please feel free to reach out. Our specialists are eager to assist you in finding solutions.

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