Nitroglycerin (NTG)-Induced Migraine Model

Creative Bioarray has developed a range of migraine models, including the nitroglycerin (NTG)-induced migraine model, to evaluate the efficacy of innovative therapeutic agents. Our commitment to excellence ensures that our models are of the highest quality, offering unparalleled reliability and accuracy for your research needs. Contact us now to learn more about how our models can support your research objectives and help bring relief to migraine sufferers worldwide.

Migraine represents one of the most debilitating neurological conditions globally, posing significant challenges for study due to its diverse manifestations, episodic nature, and the intricate neural networks involved. However, both clinical and preclinical research has significantly advanced through the utilization of NTG, as a model for migraine. NTG is a highly permeable, lipophilic, organic nitrate that has been extensively used as a model of migraine. It is its action as a nitric oxide (NO) donor that is thought to mediate its migraine-inducing effects.

Fig. 1 Overview of the translational nature of nitroglycerin (NTG) as a model of migraine in experimental clinical and preclinical research. (Sureda-Gibert, P., et al, 2022)

Our Nitroglycerin (NTG)-Induced Migraine Model

• Available Animal

• Rat
• Mouse

• Modeling Method

Animals are injected with NTG to induced migraine.

• Endpoints

• Clinical observation
• Behavioral tests
• 5-hydroxytryptamine (5-HT) and Nitric oxide (NO) analysis
• Histology analysis
• qPCR or Western blot
• Other customized endpoints

Example Data

Fig. 2 PACAP6-38 treatment ameliorated the decreased mechanical (A-B) and thermal (C) thresholds after CM. (Zhang, L., et al, 2023)

In addition, we also provide another migraine model that maybe you are interested in:

• Capsaicin-Induced Dermal Blood Flow Model

Quotation and Ordering

Creative Bioarray boasts a team of scientists with a demonstrated mastery of pharmacology and efficacy studies. We are committed to offering our clients comprehensive and personalized services of the highest quality at the most competitive prices. Our expertise enables us to tailor our approach to meet the specific needs of each project, ensuring optimal results and value for our clients. If you are interested in our services, please feel free to contact us at any time or submit an inquiry to us directly.

References

1. Zhang, L., et al. PACAP6-38 improves nitroglycerin-induced central sensitization by modulating synaptic plasticity at the trigeminal nucleus caudalis in a male rat model of chronic migraine. J Headache Pain, 2023;24(1):66.
2. Sureda-Gibert, P., et al. Nitroglycerin as a model of migraine: Clinical and preclinical review. Neurobiol Pain, 2022;12:100105.

Explore Other Options

• Cancer-Induced Bone Pain (CIBP) Model
• Inflammatory Pain Models
• Migraine Models
• Neuropathic Pain Models
• Postoperative Pain (POP) Model

• Capsaicin-Induced Dermal Blood Flow Model

For research use only. Not for any other purpose.