Ovarian Tumor Cells
Ovarian cancer remains the deadliest gynecologic malignancy, largely due to late diagnosis and the development of therapy resistance. Our collection of ovarian tumor cell lines provides essential tools for studying the complex biology of epithelial ovarian cancers (EOCs) and other ovarian tumor types.
This portfolio offers a range of well-characterized, reliable in vitro models to investigate tumorigenesis, metastasis, drug response, and mechanisms of resistance, particularly to platinum-based chemotherapies.
Relevant Authenticated Diverse Supported
Key Features & Expertise
Our ovarian tumor cell lines are designed to address critical research needs
Clinically Relevant Model Diversity
- Covers major histologic subtypes: high-grade serous, endometrioid, clear cell, and mucinous carcinomas
- Includes models with different BRCA1/2 statuses and homologous recombination proficiency/deficiency (HRD)
- Features both primary tumor-derived and metastatic ascites-derived cell lines
Comprehensive Molecular & Functional Profiling
- Genomic data on key drivers (TP53, BRCA1/2, KRAS, PIK3CA) and copy number variations
- Documented responses to standard-of-care agents (carboplatin, paclitaxel, PARP inhibitors)
- Characterized for features like spheroid formation and invasive potential, suitable for 2D and 3D assays
Quality-Certified & Supported
- Each cell line is STR-profiled for unambiguous identity verification
- Rigorously tested and certified mycoplasma-free for experimental integrity
- Supported with detailed culture protocols and batch-to-batch consistency
FAQ
Which ovarian tumor cell line is best for studying platinum resistance?
For modeling acquired platinum resistance, isogenic pairs (like sensitive parent and resistant derivative lines) are highly valuable. Many of our high-grade serous carcinoma (HGSC) models have documented platinum sensitivity/resistance profiles to help you choose.
Do you have cell lines representing different histological subtypes of ovarian cancer?
Yes. The collection includes major subtypes, with a focus on high-grade serous carcinoma (the most common), as well as clear cell, endometrioid, and mucinous carcinomas. It's important to select a model that aligns with the histology relevant to your research question.
Are BRCA-mutant ovarian cancer cell lines available?
Absolutely. We offer cell lines with known BRCA1 or BRCA2 mutations, which are crucial for studying homologous recombination deficiency (HRD) and the response to PARP inhibitors. Their mutation status is clearly detailed in the product information.
Can these models be used for 3D spheroid or organoid co-culture studies?
Many of our ovarian cancer cell lines are well-suited for 3D culture. They can form spheroids, and some are commonly used in co-culture systems with cancer-associated fibroblasts (CAFs) or mesothelial cells to study the tumor microenvironment.
How are the cell lines shipped and what are the storage recommendations?
They are shipped frozen on dry ice. For long-term storage, we recommend keeping vials in liquid nitrogen vapor phase. Detailed thawing and subculture protocols are provided with each shipment.