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Acute Radiation Syndrome (ARS) Model
Creative Bioarray offers comprehensive services to evaluate the efficacy and elucidate the mechanisms of action of your innovative therapeutic agents within our well-established models of Acute Radiation Syndrome (ARS). Our expertise enables you to explore and address the critical clinical needs that remain unmet for patients affected by ARS, thus advancing your drug development efforts and contributing to the improvement of patient care in this challenging therapeutic area.
ARS, commonly known as radiation sickness or radiation poisoning, occurs when an individual is exposed to high levels of ionizing radiation over a short period. This condition presents as an acute illness that can significantly impact three critical body systems: the bone marrow, the gastrointestinal tract (GI-ARS), and the cardiovascular/central nervous system. Currently, the treatment for ARS primarily focuses on supportive care, highlighting the urgent need for the development of additional Medical Countermeasures (MCMs). Therefore, the use of animal models is essential in the search for new therapeutic strategies to combat ARS.
Fig. 1 Subsyndromes of acute radiation syndrome. Whole-body radiation doses above approximately 0.7 Gy (in humans) result in serious radiation injury, with the hematopoietic system being affected at the lower dose range. Above 10 Gy, damage to the gastrointestinal system is observed in addition to the hematopoietic system damage. Above 50 Gy, serious damage to the central nervous system also occurs. As indicated in the figure, cell therapies may provide benefits to patients with H-ARS and/or GI-ARS but are unlikely to benefit patients with CNS-ARS. ARS, acute radiation syndrome. H-ARS, hematopoietic ARS. GI-ARS, gastrointestinal ARS. CNS-ARS, central nervous system ARS. (Christy et al. 2024)
Our Acute Radiation Syndrome (ARS) Model
- Animal Species
Rat
- Modeling Method
After acclimation, mice are treated with an X-ray radiation dose of 6Gy to induce ARS model.
Fig. 2 Modeling method of Acute Radiation Syndrome (ARS) Model
- Endpoints
- Survival rate
- Body weight
- Blood cell count
- Histology analysis
- qPCR or Western blot
- Other customized endpoints
Quotation and Ordering
Creative Bioarray is a leading research partner that specializes in providing a diverse range of rodent disease models and comprehensive services with professional expertise. In addition to our extensive collection of well-characterized models, we also offer customized model services tailored to each specific project. If you are interested in our services, please do not hesitate to contact us at any time or submit an inquiry to us directly.
Reference
- Christy, B.A., et al. Cell Therapies for Acute Radiation Syndrome. International journal of molecular sciences, 2024, 25(13): 6973.
For research use only. Not for any other purpose.
