Organoid-Immune Co-Culture Models

Organoids, which are 3D cell cultures derived from stem cells, offer exciting prospects for personalized cancer treatment and precision medicine. However, a key limitation of current organoid models is the lack of a fully integrated tumor microenvironment (TME), including immune cells and stromal components. To address this, new strategies are being developed to co-culture tumor organoids with immune cells, creating more physiologically relevant models for studying cancer therapies. This co-culture approach not only enhances our understanding of cellular interactions within the TME but also uncovers novel therapeutic targets, as well as biomarkers and neoantigens that are critical for the development of personalized cancer vaccines.

Creative Bioarray's organoid-immune co-culture models provide an innovative, highly reproducible platform for studying the interactions between tumor cells and the immune system. These models are invaluable for precision oncology, immuno-oncology, and drug development, as they enable more accurate predictions of therapeutic responses, identify new biomarkers, and help design novel cancer immunotherapies.

Cancer Immunotherapy: Organoid-immune co-cultures can model the tumor microenvironment, allowing researchers to study immune responses to tumors and test cancer immunotherapies such as checkpoint inhibitors or CAR-T cell therapies.
Infection Models: Researchers can use these models to study how pathogens, such as bacteria or viruses, interact with organoids and how the immune system responds to infections within the tissue context. This is particularly useful in studying viral infections, including COVID-19.
Autoimmune Diseases: By incorporating immune cells that mimic autoimmune conditions, organoid-immune co-cultures can provide insights into the mechanisms underlying autoimmune diseases like Crohn's disease, lupus, or rheumatoid arthritis.
Drug Development and Screening: These systems are highly relevant for testing the efficacy and toxicity of new drugs, especially those aimed at modulating the immune response. For example, immune cell modulation can be assessed in organoid models to observe potential drug effects in tissue-specific contexts.
Regenerative Medicine: Co-culturing immune cells with organoids can also help explore tissue regeneration processes and how the immune system influences tissue repair, especially in organ-specific models like liver or kidney organoids.

Figure 1. Organoid-Immune Co-Culture Models

Creative Bioarray specializes in providing advanced analysis services to support the development of cutting-edge immunotherapies. Their tailored platforms enable precise evaluation and optimization of therapies targeting complex tumor-immune interactions.

Tumor Infiltrating Lymphocyte (TIL) Therapy Analysis

Adoptive T Cell Therapy Analysis

Bi-Specific Antibody Assays

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