- You are here: Home
- Disease Models
- Pain Models
- Neuropathic Pain Models
Disease Models
- Oncology Models
-
Inflammation & Autoimmune Disease Models
- Rheumatoid Arthritis Models
- Glomerulonephritis Models
- Multiple Sclerosis (MS) Models
- Ocular Inflammation Models
- Sjögren's Syndrome Model
- LPS-induced Acute Lung Injury Model
- Peritonitis Models
- Passive Cutaneous Anaphylaxis Model
- Delayed-Type Hypersensitivity (DTH) Models
- Inflammatory Bowel Disease Models
- Systemic Lupus Erythematosus Animal Models
- Asthma Model
- Sepsis Model
- Psoriasis Model
- Atopic Dermatitis (AD) Model
- Scleroderma Model
- Gouty Arthritis Model
- Carrageenan-Induced Air Pouch Synovitis Model
- Carrageenan-Induced Paw Edema Model
- Experimental Autoimmune Myasthenia Gravis (EAMG) Model
- Cardiovascular Disease Models
-
Neurological Disease Models
- Alzheimer's Disease Modeling and Assays
- Seizure Models
- Parkinson's Disease Models
- Ischemic Stroke Models
- Acute Spinal Cord Injury (ASCI) Model
- Traumatic Brain Injury (TBI) Model
- Hypoxic-Ischemic Encephalopathy (HIE) Model
- Tourette Syndrome (TS) Model
- Amyotrophic Lateral Sclerosis (ALS) Model
- Huntington's Disease (HD) Model
- Intracerebral hemorrhage (ICH) Models
- Pain Models
- Metabolic Disease Models
- Liver Disease Models
- Rare Disease Models
- Respiratory Disease Models
- Digestive Disease Models
-
Urology Disease Models
- Cisplatin-induced Nephrotoxicity Model
- Unilateral Ureteral Obstruction Model
- 5/6 Nephrectomy Model
- Renal Ischemia-Reperfusion Injury (RIRI) Model
- Diabetic Nephropathy (DN) Models
- Passive Heymann Nephritis (PHN) Model
- Adenine-Induced Chronic Kidney Disease (CKD) Model
- Kidney Stone Model
- Doxorubicin-Induced Nephropathy Model
- Orthopedic Disease Models
- Ocular Disease Models
Neuropathic Pain Models
Creative Bioarray, a leading company specializing in in vivo pharmacological efficacy evaluation, has developed a comprehensive range of neuropathic pain models to facilitate the acceleration of drug development processes for our clients. By leveraging our expertise in pain research and our advanced preclinical models, we enable our clients to efficiently assess the efficacy of their therapeutic candidates, thereby reducing the time and resources required for drug development.
Neuropathic pain is caused by a lesion or disease of the somatosensory system, including peripheral fibers (Aβ, Aδ, and C fibers) and central neurons, and affects 7–10% of the general population. Multiple causes of neuropathic pain have been described and its incidence is likely to increase owing to the aging global population, increased incidence of diabetes mellitus, and improved survival from cancer after chemotherapy. Indeed, imbalances between excitatory and inhibitory somatosensory signaling, alterations in ion channels, and variability in the way that pain messages are modulated in the central nervous system all have been implicated in neuropathic pain. In the pursuit of a deeper understanding and more effective treatments for neuropathic pain, disease models serve as invaluable tools for researchers. These models are meticulously designed to replicate the clinical features and underlying pathophysiology of neuropathic pain, offering a controlled environment to investigate its mechanisms, assess potential therapeutic interventions, and ultimately advance the field of pain management.
Fig. 1 The peripheral and central changes induced by nerve injury or peripheral neuropathy. (Colloca et al. 2017)
Our Animal Models of Neuropathic Pain
Creative Bioarray has created a suite of neuropathic pain models designed to replicate the spectrum of clinical pain scenarios with varying causes. These include peripheral nerve injury models, anti-cancer agents-induced neuropathy models, and diabetes-induced neuropathy models. Details are as follows.
- Diabetes-Induced Neuropathic Pain Model
- Chemotherapy-Induced Neuropathic Pain Model
- Chronic Constriction Injury (CCI) Model
- Spared Nerve Injury (SNI) Model
- Partial Sciatic Nerve Ligation (PSL/PSNL) Model
- Spinal Nerve Ligation (SNL) Model
Quotation and Ordering
Creative Bioarray offers our clients cost-effective services at the highest standards of quality and accuracy. We are delighted to contribute our expertise in efficacy studies to enhance our clients' exceptional studies. If you are interested in our services, please contact us at any time or submit an inquiry to us directly. We look forward to cooperating with you.
Reference
- Colloca, L., et al. Neuropathic pain. Nature reviews Disease primers, 2017, 3(1): 1-19.
For research use only. Not for any other purpose.
