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Humanized CD34+ HSC Models
Creative Bioarray has successfully engineered sophisticated humanized mouse model featuring CD34+ hematopoietic stem cells (HSCs), meticulously designed for cutting-edge drug efficacy studies, particularly focused on cancer therapeutics. These innovative models are crafted to closely mimic the human immune system, providing an invaluable platform for in-depth investigation of tumor drug responses and interactions within a human-like physiological context. They are specifically optimized to assess the efficacy and safety of novel cancer drugs, offering a highly relevant environment for preclinical evaluation of therapeutic agents against a wide range of malignancies.
Humanized CD34+ HSC Model in Creative Bioarray
Humanized CD34+ HSC Model represents a state-of-the-art in vivo platform, meticulously crafted for the evaluation of compounds that engage with the human immune system, with a particular focus on the assessment of anti-cancer therapies. This innovative model is distinguished by its minimal occurrence or delayed onset of graft-versus-host disease (GvHD), rendering it ideal for extended research studies. In this model, CD34+ stem cells, sourced from human umbilical cord blood, are transplanted into immunodeficient mice. Following this transplantation, the stem cells colonize the mouse bone marrow, where they continuously generate a diverse array of human hematopoietic and immune cells, including T cells, B cells, NK cells, and myeloid cells. This unique capability of the Humanized CD34+ HSC Model to support the development and function of the human immune system within a mouse environment provides an invaluable tool for the in-depth investigation of immune responses and the efficacy of novel anti-tumor drugs, making it a pivotal platform for advancing cancer immunotherapy research.
Fig. 1 Schematic of Humanized CD34+ HSC Model.
Features of Humanized CD34+ HSC Models
- Humanized Background: Through the engraftment of human CD34+ HSCs into mice, we establish a mouse model that embodies key features of the human immune system.
- Broad Applications: Applicable across a wide range of tumor types, this model caters to a broad spectrum of research objectives.
- Customization Flexibility: The model is highly adaptable, allowing for customization and refinement to meet specific research needs.
Research Application
Example Data
Fig. 2 Effects of the test compound on tumor volume and body weight in a humanized CD34+ HSC mouse model implanted with A-375 cells.
Fig. 3 Effects of the test compound on tumor volume and body weight in a humanized CD34+ HSC mouse model implanted with NUGC4 cells.
Quotation and Ordering
Creative Bioarray has successfully developed a series of stable humanized mouse models tailored for advanced tumor research. Our team of seasoned scientists has meticulously validated both our extensive portfolio of human xenografts and the humanized mouse models. These models are designed to closely mimic human tumor biology, providing an invaluable platform for in-depth investigation of cancer progression, therapeutic response, and the complex interactions between human tumors and the immune system. If you are interested in our services, please feel free to contact us at any time or submit an inquiry to us directly.
For research use only. Not for any other purpose.
