Complete Freund's Adjuvant (CFA)-Induced Inflammatory Pain Model

As a trusted research partner in the field of preclinical drug development, Creative Bioarray prides itself in offering an extensive array of innovative inflammatory pain models. These models serve as a robust platform for establishing the proof-of-concept, facilitating the potential assessment, and advancing the development of effective treatment strategies for a diverse range of pain-related medical conditions. By leveraging our expertise in inflammatory pain research, we aim to contribute significantly to the advancement of pain management and improve the quality of life for patients suffering from various pain disorders.

CFA is composed of mineral oil containing a suspension of whole or pulverized heat-killed mycobacteria. Its adjuvant activity is attributed to the sustained release of antigens from the oily depot and the stimulation of a local innate immune response, resulting in a delayed hypersensitivity reaction at the injection site, characterized by intense inflammation and hyperalgesia. The CFA-induced inflammatory pain model has been well characterized in Creative Bioarray and is routinely used for screening novel compounds targeted for inflammatory pain.

Our Complete Freund's Adjuvant (CFA)-Induced Inflammatory Pain Model

• Available Animal

• Rat
• Mouse

• Modeling Method

Animals undergo an intraplantar injection of CFA into the hind paw to induce inflammatory pain.

• Endpoints

• Behavioral tests: Von Frey test, Hot plate test, etc.
• Body weight
• Clinical observation
• qPCR or Western blot
• Histology analysis
• Other customized endpoints

Example Data

Fig. 1 CFA-induced mechanical allodynia. (Zhu et al. 2022)

Fig. 2 CFA-induced thermal hyperalgesia. (Zhu et al. 2022)

In addition, we also provide other inflammatory pain models that maybe you are interested in:

• Formalin-Induced Inflammatory Pain Model
• Capsaicin-Induced Inflammatory Pain Model
• Carrageenan-Induced Inflammatory Pain Model

Quotation and Ordering

As a preeminent preclinical CRO partner, Creative Bioarray offers our clients swiftly scheduled, cost-effective, and impeccably precise services, adhering to the utmost standards of quality. If you are interested in our services, please feel free to contact us at any time or submit an inquiry to us directly.

References

1. Zhu C, Wang M, Guo J, et al. Angelica dahurica Extracts Attenuate CFA-Induced Inflammatory Pain via TRPV1 in Mice. Evid Based Complement Alternat Med. 2022; 2022:4684830.
2. Navarro-Alvarez N, Gonçalves BMM, Andrews AR, Sachs DH, Huang CA. A CFA-Induced Model of Inflammatory Skin Disease in Miniature Swine. Int J Inflam. 2018; 2018:6916920.

Explore Other Options

• Cancer-Induced Bone Pain (CIBP) Model
• Inflammatory Pain Models
• Migraine Models
• Neuropathic Pain Models
• Postoperative Pain (POP) Model

• Capsaicin-Induced Inflammatory Pain Model
• Carrageenan-Induced Inflammatory Pain Model
• Formalin-Induced Inflammatory Pain Model

For research use only. Not for any other purpose.