Organoid Models

Creative Bioarray offers state-of-the-art organoid models that facilitate groundbreaking research in drug discovery, disease modeling, and regenerative medicine. These 3D culture systems replicate the architecture and functionality of human tissues, providing data that is more physiologically relevant than traditional 2D cultures.

• Patient-Derived Cancer Organoids (PDCOs)
  Patient-Derived Cancer Organoids (PDCOs) are cultured from patient tumor tissues and replicate the genetic, phenotypic, and functional characteristics of the original tumors. This technology enables the development of in vitro models that closely mimic individual patient cancers, offering a powerful tool for personalized medicine and cancer research.

Figure 1. Construction of living PDCO biobank with clinical and genomic information. ^[1]

• Patient-Derived Xenografts Organoids (PDXOs)  
  Patient-Derived Xenograft Organoids (PDXOs) combine the benefits of patient-derived xenografts (PDXs) and organoid technology. PDXs are tumors that are directly transplanted from patients into immunocompromised mice, preserving the histological and molecular characteristics of the original tumors.

Figure 2. Establishment of PDXOs that reflect phenotypic and transcriptomic profiles of matching PDX and patient tumors. ^[2]

• Pluripotent Stem Cell (PSC)-Derived Organoids
  Pluripotent stem cell (PSC)-derived organoids closely mimic the architecture and function of real organs. These organoids are generated from PSCs, which include embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). PSCs can differentiate into any cell type, enabling the creation of a diverse range of organoid models for research, drug development, and disease modeling.

Figure 3. Schematic of the different organoids that can be derived from PSCs.^[3]

Creative Bioarray has introduced a variety of disease organoid models to advance research in drug discovery, disease modeling, and regenerative medicine.

• Breast Organoids
• Lung Organoids
• Cholangiocarcinoma Organoids
• Colorectal Organoids
• Brain Organoids
• Liver Organoids
• Breast Organoids

References

1. Bae, JuneSung et al. "The Patient-Derived Cancer Organoids: Promises and Challenges as Platforms for Cancer Discovery." Cancers vol. 14,9 2144. 25 Apr. 2022, doi:10.3390/cancers14092144
2. Van Hemelryk, Annelies et al. "Patient-Derived Xenografts and Organoids Recapitulate Castration-Resistant Prostate Cancer with Sustained Androgen Receptor Signaling." Cells vol. 11,22 3632. 16 Nov. 2022, doi:10.3390/cells11223632
3. Tang, Xiao-Yan et al. "Human organoids in basic research and clinical applications." Signal transduction and targeted therapy vol. 7,1 168. 24 May. 2022, doi:10.1038/s41392-022-01024-9

Explore Other Options

• 3D Spheroid & Organoid Culture Reagents
• 3D Spheroid Platform for Drug Development
• Genetic Engineering in Organoids
• Organoid Platform for Drug Development
• Organ-on-a-Chip Platform for Drug Development

• Organoid-based High-throughput Screening
• Organoid-Immune Co-Culture Models

For research use only. Not for any other purpose.