Disease Models

Efficacy studies of lead candidates in animal disease models are vital for preclinical candidate selection in drug discovery. The relevant disease models and DMPK assays are used to study the biological effects of drug candidates. Creative Bioarray has established multiple animal disease models including cardiovascular disease models, chronic liver disease models, metabolic disease models, neurological disease models, oncology models, etc. We provide validated and custom in vivo disease modeling and services. Our comprehensive animal-based disease models of different organ systems allow our clients to choose the most appropriate models to test promising compounds and optimize lead candidates.

Disease Models

Available in vivo disease models:

Oncology Models
- Cell line-derived xenograft models (CDX)
- Patient-derived xenograft models (PDX)
- Syngeneic and orthotopic models
- Gene-edited animal models
- Chemically induced animal models
Neurological Disease Models
Gastrointestinal Disease Models
Cardiovascular Disease Models
Liver Disease Models
- Alcoholic liver disease model
- Liver fibrosis model
- Acute liver injury
- Chronic liver injury
- Chronic fatty liver disease
- Alcoholic steatohepatitis (ASH) & non-Alcoholic steatohepatitis (NASH)
Metabolic Disease Models
- Type 1 diabetes mellitus model
- Type 2 diabetes mellitus model
- Animal model of hyperuricemia
- Nonalcoholic fatty liver disease (NASH) model
- High fat diet-induced obesity model
- Dyslipidemia
- Obesity
- Organ damage (UUO, CKD)
Respiratory Disease Models

Ocular Disease Models
- Inflammatory disorders
- Eye irritation
- Retinopathy of prematury
- Stromal ulceration
- Corneal graft
- Infectious keratitis
- Diabetic retinopathy
Inflammation & Autoimmune Disease Models
- Rheumatoid arthritis models
- Nephritis models
- Multiple sclerosis (MS) models
- Ocular inflammation models
  - Endotoxin induced uveitis (EIU)
  - Experimental autoimmune uveitis (EAU)
- Sjögren's syndrome model
- LPS-induced acute lung injury model
- Peritonitis models
- Passive cutaneous anaphylaxis model
- Delayed-type hypersensitivity models
- Inflammatory bowel disease models
- Systemic lupus erythematosus animal models
- Oral mucositis model
- Asthma model
- Sepsis model
- Psoriasis model
- Atopic dermatitis (AD) model
- Scleroderma model
- Gouty arthritis model
- Carrageenan-Induced Air Pouch Synovitis Model
- Carrageenan-Induced Paw Edema Model
- Experimental Autoimmune Myasthenia Gravis (EAMG) Model
- Graft-versus-host Disease (GvHD) Model
Orthopedic Disease Models
Urology Disease Models
Rare Disease Models
- Huntington's disease
- Amyotrophic lateral sclerosis (ALS)
- Batten disease
- Multiple sclerosis (MS)
- Systemic lupus erythematosus (SLE)
- Muscular dystrophy
Pain Models
Surgical Models
- Cisterna magna cannulation
- Bile duct cannulation
- Portal vein cannulation
- Thoracic duct cannulation
- Intraduodenally administration

Each of the above disease models is designed to understand specific aspects of drug property and its mechanism of action. Besides, the animals used for studies are provided by certified animal suppliers. All study protocols and animal use are approved by IACUC. By accessing our comprehensive capability, our customers can advance their drug discovery projects faster.

Contact us for more information on the listed disease models or if you would like to customize a new model to meet your particular needs. With all our In Vivo Services, we ensure continuous communications and discussions during on-going studies. Please feel free to contact us to find out more about our capabilities and services.

Explore Other Options

For research use only. Not for any other purpose.

Disease Models

Available in vivo disease models:

Orthopedic Disease Models

Surgical Models