- You are here: Home
- Disease Models
- Cardiovascular Disease Models
- Animal Models of Hypertension
- DOCA-Salt Model
Disease Models
- Oncology Models
-
Inflammation & Autoimmune Disease Models
- Rheumatoid Arthritis Models
- Glomerulonephritis Models
- Multiple Sclerosis (MS) Models
- Ocular Inflammation Models
- Sjögren's Syndrome Model
- LPS-induced Acute Lung Injury Model
- Peritonitis Models
- Passive Cutaneous Anaphylaxis Model
- Delayed-Type Hypersensitivity (DTH) Models
- Inflammatory Bowel Disease Models
- Systemic Lupus Erythematosus Animal Models
- Asthma Model
- Sepsis Model
- Psoriasis Model
- Atopic Dermatitis (AD) Model
- Scleroderma Model
- Gouty Arthritis Model
- Carrageenan-Induced Air Pouch Synovitis Model
- Carrageenan-Induced Paw Edema Model
- Experimental Autoimmune Myasthenia Gravis (EAMG) Model
- Cardiovascular Disease Models
-
Neurological Disease Models
- Alzheimer's Disease Modeling and Assays
- Seizure Models
- Parkinson's Disease Models
- Ischemic Stroke Models
- Acute Spinal Cord Injury (ASCI) Model
- Traumatic Brain Injury (TBI) Model
- Hypoxic-Ischemic Encephalopathy (HIE) Model
- Tourette Syndrome (TS) Model
- Amyotrophic Lateral Sclerosis (ALS) Model
- Huntington's Disease (HD) Model
- Intracerebral hemorrhage (ICH) Models
- Pain Models
- Metabolic Disease Models
- Liver Disease Models
- Rare Disease Models
- Respiratory Disease Models
- Digestive Disease Models
-
Urology Disease Models
- Cisplatin-induced Nephrotoxicity Model
- Unilateral Ureteral Obstruction Model
- 5/6 Nephrectomy Model
- Renal Ischemia-Reperfusion Injury (RIRI) Model
- Diabetic Nephropathy (DN) Models
- Passive Heymann Nephritis (PHN) Model
- Adenine-Induced Chronic Kidney Disease (CKD) Model
- Kidney Stone Model
- Doxorubicin-Induced Nephropathy Model
- Orthopedic Disease Models
- Ocular Disease Models
DOCA-Salt Model
DOCA-salt animal is the model that represent the form of endocrine hypertension in humans with primary aldosteronism. Administration of DOCA combined with sodium chloride in unilateral nephrectomised rats cause an imbalance of renal sodium handling, resulting in hypertension. In addition, DOCA-salt rats/mice have increased arterial wall thickness, renal function damage and so on. Though the exact mechanism of hypertension in DOCA-salt rats remain unclear, increasing evidence indicates that the occurence of DOCA-salt hypertension associates with the overactive sympathetic nervous system and an imbalance in the reninangiotensin system (RAS). Thus, this model is ideal for studying the role of the above single pathways on hypertension pathogenesis.
Creative Bioarray focuses on drug research and development services and helps customers test the efficacy of novel drugs against hypertension and understand the pathological mechanisms by DOCA-Salt model.
Species available
- Rat
- Mouse
Our capabilities
- We screen novel test compounds targeting hypertension.
- Blood pressure (BP) was monitored by tail-cuff.
Assays available
- PK/PD collection
- Pathological evaluation
- Cytokine analysis
- ECG
- Blood pressure monitoring
With extensive experience in the field of hypertension, we are confident to help you to overcome any upcoming challenges. Our experts are fully capable of customizing our protocols and assays to meet your specific needs. With our help, we wish to facilitate your research with high efficiency.
Study examples
Figure. 1. MCC950 reduces BP in mice with 1K/DOCA/salt-induced hypertension. Effects of 1K/DOCA/salt and MCC950 on systolic BP (A), diastolic BP (B), mean arterial pressure (C), and heart rate (D) measured by radiotelemetry at 10 min-intervals and plotted as an average over a 3-day period.
Quotation and ordering
If you have any special needs or questions regarding our services, please feel free to contact us. We look forward to cooperating with you in the future.
Reference
Krishnan S M, Ling Y H, Huuskes B M, et al. Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension[J]. Cardiovascular research, 2018, 115(4): 776-787.
For research use only. Not for any other purpose.