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Disease Models
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Urology Disease Models
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PDX-based Drug Screening
- Service Details
- Features
- FAQ
Patient-derived xenograft (PDX) models have become an indispensable tool in cancer research, largely owing to their ability to accurately re-create the biology of human tumors. PDX models, by implanting human tumor tissue in immune-deficient mice, produce tumors very similar to the original tumors, both in histopathology, genetics, and therapeutic response. An important breakthrough in the PDX model is the re-establishment of human immune system, making it possible to study similar immune responses in humans, especially in the development of immunotherapies.
The PDX models are different in that they replicate the heterogeneity and biology of human tumors and thus have a greater predictive value than cell line models. It allows scientists to gain a full picture of cancer, and to personalize drug therapies. In the field of drug screening, they give the ability to assess heterogeneity among tumors by allowing drug responses to be evaluated across a wide range of cancer types and patient-derived samples. Drug screening using PDX models can identify therapeutic targets and determine efficacy at a more translational level. This leads to a more stratified and individualized cancer treatment planning and better chances of clinical success in new drug development.
Fig. 1. Use of PDX models in drug screening and preclinical therapeutic evaluation (Lai Y, Wei X, et al., 2017).
With Creative Bioarray's advanced PDX model construction technology and years of experience, we provide our customers with comprehensive PDX model construction services to facilitate accurate and effective oncology drug screening.
Advantages of PDX models
- Preserves the genotypic and expressive diversity of the patient's tumor tissue.
- Preserves the original tumor stroma and microenvironment.
- Accurately mirror the patient's mechanism of tumorigenesis and development
- Accurate drug sensitivity and tolerance assessment.
Applications
- PDX models are employed in cancer biology and drug resistance studies to identify cancer-specific biomarkers.
- For discovery and evaluation of potential cancer drugs, e.g., in testing chemotherapeutics, antibody therapies, and microbial therapies.
- Provide unlimited sources of tumor cells in high-throughput screening of cancer drugs.
- Corresponding PDOs or PDXOs to test new drug therapies.
- Immunotherapy studies.
Available Tumor Types, Including but Not Limited to:
Adrenal Gland Cancer
Breast Cancer
Colorectal Cancer
Esophageal Cancer
Gallbladder Cancer
Liver Cancer
Melanoma
Mixed Mullerian Cancer
Pancreatic Cancer
Thyroid Cancer
Bladder Cancer
Cholangiocarcinoma
Cervical Cancer
Gastric Cancer
Head and Neck Cancer
Lung Cancer
Mesothelioma
Ovarian Cancer
Prostate Cancer
Uterine Cancer
Host Animal
- Nude mice
- SCID mice
- Humanized mouse model
Features
- Our team consists of experienced researchers to ensure high quality and efficiency in PDX model construction and drug testing.
- Have successfully constructed PDX models for a variety of tumor types with rich data support
- Flexibility to adjust the experimental design according to customer's specific project needs.
FAQ
1: How to ensure that the biological properties of the PDX model are consistent with the patient's primary tumor?
We validate the PDX model by histology and imaging to make sure its biology is highly correlated with the patient's primary tumor, and we closely track the model's stability.
2: What types of PDX models do you have available?
Our PDX models cover a variety of common tumors, including Bladder, Breast, Colorectal, Liver, Lung, Ovarian, Uterine Cancer, etc. For other tumor types not listed, you can consult our service team, and we will provide you with detailed answers.
3: How many animals are generally required for each group in PDX-based drug testing?
In our PDX-based drug testing, the preliminary experiment typically consists of 4 groups with 6 animals each; the formal experiment consists of 8-10 animals per group.
Quotation and Ordering
With our extensive experience in the field of PDX modeling, we are confident that we can offer to help you conquer any upcoming challenges. If you have any special needs or questions about our services, please contact us at any time. We look forward to serving you in the future.
For research use only. Not for any other purpose.
