Respiratory Toxicity

For every breath we take, air passes through the mouth and/or nasal cavity and then through the trachea, bronchus, and bronchioles before entering lung, where gas exchange occurs. However, many inhaled toxins bypass these defense mechanisms of lung, or become activated by the metabolic enzymes, leading to pulmonary toxicity and acute injury to the lung epithelia. Proper identification of potential respiratory toxins and irritants is important to numerous industries, including chemical, personal care, and pharmaceutical industries.

Many respiratory toxicity identification methods have been established in the past, such as human research, and animal study. However, pulmonary research in humans is obviously limited due to the human and ethics issues; and for whole-animal inhalation studies, significant cost and time considerations are associated.

Nowadays, an improvement has been made by using three-dimensional (3D) human derived respiratory tissue model to predict the respiratory toxicity of compounds and chemicals. These tissues exhibits human relevant tissue structure and cellular morphology with high uniformity and reproducibility, and allows for in vitro respiratory toxicity testing of compounds such as pathogens, chemicals or therapeutics.

With over 10 years’ experience of working on cell & tissue products and services, Creative Bioarray provides in vitro airway tissue model and in vitro respiratory toxicity test to help chemical, personal care, and pharmaceutical industries to evaluate respiratory toxicity potential for their chemicals and products.

Your Needs

• You are looking for in vitro airway tissue model for your researches?
• You wish to evaluate respiratory toxicity potential for your ingredients, products or chemicals?
• You’d like to find a customized service related to respiratory toxicity?

Our Capability

In vitro 3D Models Available

• In vitro airway tissue model

- Creative Bioarray's in vitro airway tissue model could be applied to in vitro respiratory toxicity testing, it is very similar to in vivo airway mucosa in terms of morphology, of differentiation markers and of functional characteristics.

• Ex vivo airway tissue model
• Respiratory cells and lung cells

Assays available

• Cytotoxicity test: Assessment for the presence of leakage markers such as lactate dehydrogenase (LDH) or adenylate kinase (AK), two hallmark leakage markers.
• Tissue viability test: MTT assay, WST-8 assay, and ATP content assay.
• Histology assessment: Histological assessment of stained tissues is available, with focused viability determinations possible.
• Contact us about your custom evaluation requirements.

Assay Examples

Fig.1 (a) Cytotoxicity test; (b) Tissue viability test for different chemicals by using in vitro tissue model

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Explore Other Options

• 3D Spheroid & Organoid Culture
• Cell Therapy
• Mucosa
• Neurological Disorder Modeling and Assays
• Oncology

• In vitro Eye Irritation Test
• Oral Irritation Test

For research use only. Not for any other purpose.