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Inflammation & Autoimmune Disease Models
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Graft-versus-host Disease (GvHD) Models
Creative Bioarray has successfully developed Graft-versus-host Disease (GvHD) models that provide a robust and versatile platform for evaluating the efficacy of novel treatments and exploring mechanisms of immunoregulation. Our comprehensive services enable researchers to obtain reliable and reproducible results, significantly accelerating the pace of their research projects.
Hematopoetic stem cell transplantation (HSCT) is a potentially curative procedure for hematological malignancies of the blood and bone marrow. It can replenish the immune compartment and may induce beneficial anticancer effects referred to as graft-versus-tumor (GVT) activity. Unfortunately, GvHD is a serious complication in patients receiving HSCT, causing substantial morbidity and mortality. The disease is triggered by the reactivity of donor-derived immune cells against allogeneic recipient tissues and is a major unmet medical need with limited treatment options.
Fig. 1 Pathophysiology of GvHD. (Welniak et al. 2007)
Our Animal Models of Graft-versus-host Disease (GvHD)
Allogenic Bone Marrow Transplantation-Induced GvHD Model
Human PBMC Transplantation-Induced GvHD Model
Quotation and Ordering
Creative Bioarray is proud to offer our advanced technology and comprehensive expertise in rodent disease models to support our clients in advancing their research and developing their projects. We are committed to providing innovative solutions and specialized knowledge to enhance the success of our clients' drug development. If you are interested in our services, please feel free to contact us at any time or submit an inquiry to us directly.
Reference
- Welniak, L.A, et al. Immunobiology of allogeneic hematopoietic stem cell transplantation. Annu. Rev. Immunol, 2007, 25(1): 139-170.
For research use only. Not for any other purpose.
