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Allogeneic Bone Marrow Transplantation-Induced GvHD Model
Creative Bioarray has established a Graft-versus-host Disease (GvHD) model that is initiated through allogeneic bone marrow transplantation. This model serves as a robust platform for screening compounds and conducting comprehensive assessments of the efficacy of molecules. To facilitate detailed analysis, we have developed a comprehensive suite of endpoint analysis tools. These tools encompass a variety of techniques, such as molecular biology and biochemical assays, as well as histological and morphological evaluations. These methodologies enable researchers to gain deep insights into the mechanisms of action and therapeutic potential of their compounds within the context of GvHD.
GvHD is a critical inflammatory complication that can arise following allogeneic hematopoietic stem cell transplantation (HSCT), affecting up to 50% of recipients. This condition occurs when the donor's immune cells identify the recipient's tissues as foreign, initiating an immune response that results in tissue damage and inflammation. The allograft GvHD model, specifically the H2b to H2d MHC-mismatched model, is a cornerstone in preclinical research. It is instrumental in elucidating the pathophysiology of GvHD and in evaluating potential therapies aimed at mitigating this common post-transplant complication.
Our Allogeneic Bone Marrow Transplantation-Induced GvHD Model
- Available Animal
- Mouse
- Modeling Method
Bone marrow from C57BL/6 (H2b) mice is injected into irradiated BALB/c (H2d) mice to induce GvHD.
Fig. 1 Modeling method of Allogeneic bone marrow transplant GvHD model
- Endpoints
- Body weight
- Clinical score
- Cytokine analysis
- Survival rate
- Flow cytometry
- Histology analysis
- qPCR or Western blot
- Other customized endpoints
Example Data
Fig 2. Pathological findings and analysis: (a,b) H&E and Mallory staining of lacrimal glands (LGs) and skin and from non-treated cGVHD mice (left) and gentamicin-treated cGVHD mice (+GM) (right); (c) Blue fibrotic areas indicated by Mallory staining were measured using ImageJ (n = 5 per group; 3 fields). (Sato et al. 2021)
In addition, we also provide another GvHD model that maybe you are interested in:
Quotation and Ordering
Creative Bioarray offers top-tier preclinical services that are cost-effective and time-efficient, ensuring the highest standards of quality and precision. Our team of dedicated scientists collaborates closely with clients to identify the most appropriate models for their research needs. If you are interested in our services, please feel free to contact us at any time or submit an inquiry to us directly.
Reference
- Sato, S., et al. Positive effects of oral antibiotic administration in murine chronic graft-versus-host disease. International journal of molecular sciences, 2021, 22(7): 3745.
For research use only. Not for any other purpose.
