Skeletal Muscle Cells

Here you can find skeletal muscle cells, satellite cells and myoblasts. You can also find media to grow the cells as well as DNA, RNA and proteins derived from these cells.

Skeletal Muscle Cells

Skeletal muscle cells (SkMC), one of the largest cell types in the human body, are multinucleated cells formed by the fusion of myoblasts. SkMC generate force for movement, and function in heat production, posture support, metabolic homeostasis and regulation. Their metabolic dysfunction leads to various diseases. Cultured SkMC provide ideal models for studying muscle cell biology, diabetes, muscle cell metabolism, muscle tissue repair, and myotube development.

Skeletal Muscle Satellite Cells

The physiology of skeletal muscle is critically dependent on the function of a progenitor cell population called "satellite cells", which account for about 1% of the total muscle nuclei, located between the plasma membrane of the multinucleated muscle cells and the basal layer surrounding each myofiber. In adult muscle, satellite cells are quiescent but proliferate and differentiate to form multinucleated myofibers in response to muscle injury. Defects in satellite cell function can lead to loss of muscle mass and decline in performance that is frequently observed in chronic diseases and aging.

Skeletal Muscle Myoblasts

Myoblasts are mononuclear myogenic precursor cells that can regenerate skeletal muscle through proliferation. During their proliferation, they will eventually fuse and integrate into multinucleated myotubes, which then mature into myofibers. This process occurs during the embryonic histogenesis of muscle and in postnatal muscle regenerating in response to injury, or in myopathies such as Duchenne muscular dystrophy. Human skeletal muscle myoblast culture is a convenient in vitro model for the study of cell development and differentiation, insulin metabolism and tissue repair.