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Immortalized Murine Cells
Murine cells show frequent spontaneous immortalization in contrast to human cells that almost never spontaneously immortalize. Addition of DNA tumor viruses alone, mild mutagen treatments and even deregulated expression of cellular genes such as c-myc are enough in certain murine cells for immortalization. Crisis stage is either not observed or is very subtle in case of murine cells, due to their ability to immortalize spontaneously, were exploited to identify genes associated with cellular mortal or immortal phenotypes. Independent studies on spontaneously immortalized clones from different strains of mouse have shown that most of these clones had one or both mutant p53 alleles, in contrast to their parent cells which expressed wild type p53. The immortal clones which expressed wild type p53 were found to be defective in one or other elements of the pRb pathway.
Creative Bioarray can provide you immortalized murine cell lines with an integrated platform for meeting the needs for virtually any relevant research project.
Description: The olfactory bulb is located within the vertebrate forebrain, in which it functions...
Description: Immortalized MHC II -/- Mouse Macrophage Cells (C2Dt) is derived from the knockout...
Description: Immortalized Mouse Proximal Tubule KPT2 Cells are spontaneously immortal derived...
Description: Immortalized Rat Embryonic Striatal (M213-2O) Cells - tsSV40T has GABAgeric properties...
Description: The olfactory bulb is located within the vertebrate forebrain, in which it functions...
Description: Immortalized Mouse CD81−/− Macrophage Cells (ASD1) is established from the long bones...
Description: Immortalized MHC II -/- Mouse Macrophage Cells (C2D) is derived from the knockout...
Description: Immortalized Rat Embryonic Striatal (M26-1F) Cells - tsSV40T has GABAgeric properties...
Description: Immortalized mouse suture osteoblast cells (iSOCs) are immortalized through infection...
Description: Immortalized Mouse Cranial Suture Cells (iMSu) are immortalized through infection...
Description: Immortalized mouse neural progenitor cells (iNPCs) are immortalized through infection...
Description: Immortalized Mouse CD81−/− Macrophage Cells (ASD1) is derived from the long bones...
Description: Immortalized Mouse Erythoid Progenitor Cell Line (CD36E) - HPV16 E6/E7 are derived...
Description: Immortalized mouse glial cells (iGlia) are immortalized through infection with non-replicating...
Description: The Immortalized Mouse Preadipocyte Cells (ScAP-23) was isolated from subcutaneous...
Description: Immortalized Rat Mesencephalic (AF5) Cells - SV40T are derived from E-14 rat embryos...
Description: Immortalized Rat Embryonic Striatal Wildtype (121-1I) Cells are immortalized with...
Description: Immortalized mouse adipose-derived mesenchymal cells (iMADs) are immortalized through...
