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Immortalized Murine Cells
Murine cells show frequent spontaneous immortalization in contrast to human cells that almost never spontaneously immortalize. Addition of DNA tumor viruses alone, mild mutagen treatments and even deregulated expression of cellular genes such as c-myc are enough in certain murine cells for immortalization. Crisis stage is either not observed or is very subtle in case of murine cells, due to their ability to immortalize spontaneously, were exploited to identify genes associated with cellular mortal or immortal phenotypes. Independent studies on spontaneously immortalized clones from different strains of mouse have shown that most of these clones had one or both mutant p53 alleles, in contrast to their parent cells which expressed wild type p53. The immortal clones which expressed wild type p53 were found to be defective in one or other elements of the pRb pathway.
Creative Bioarray can provide you immortalized murine cell lines with an integrated platform for meeting the needs for virtually any relevant research project.
Description: The Immortalized Mouse CD4+CD8+T Cells (MOHITO) has characteristics of an immortalized...
Description: Immortalized Mouse Renal Proximal Tubule Cells-SV40 have been obtained immortalizing...
Description: Odontoblasts are useful in studying the development of mineralized tissue, such as...
Description: Immortalized Rat Suprachiasmatic Nucleus Cells (SCN2.2) is pluripotent and has the...
Description: Epidermal melanocytes are melanin-producing cells that function as a protective mechanism...
Description: During preganancy the myometrium undergoes hypertrophy and hyperplasia. The established...
Description: The Immortalized Mouse Urogenital Sinus Mesenchymal Cells (UGSM-2) are derived from...
Description: The Immortalized Mouse Leptin Receptor-deficient Macrophage Cells (DB-1) are non-transformed...
Description: The Immortalized Adult Mouse Ventral Prostate Cells (INK4 -/- VP) were derived from...
Description: The Immortalized Adult Mouse Dorsolateral Prostate Cells (INK4 -/- DLP) were derived...
Description: The Immortalized Adult Mouse Cogulating Gland Cells (INK4 -/- CG)are derived from...
Description: A clonal derivative from the CD3-NK1.1+NK cells developed from cocultures of OP-9S/LMJSN...
Description: Immortalized Mouse Proximal Tubule KPT11 Cells are spontaneously immortal derived...
Description: The bone morphogenetic proteins (BMPs) produced by calvarial cells are crucial in...
Description: Activated primary rat portal fibroblasts (PF) were immortalized with the SV40 large...
Description: Immortalized Mouse Kupffer Cells (ImKC) are isolated from male H-2Kb-tsA58 transgenic...
Description: The Immortalized Mouse Spleen Dendritic Cell (SRDC) line is functionally and phenotypically...
Description: The Immortalized Mouse Epidermal Cells (COCA) retains its capacity to differentiate...
