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Immortalized Murine Cells
Murine cells show frequent spontaneous immortalization in contrast to human cells that almost never spontaneously immortalize. Addition of DNA tumor viruses alone, mild mutagen treatments and even deregulated expression of cellular genes such as c-myc are enough in certain murine cells for immortalization. Crisis stage is either not observed or is very subtle in case of murine cells, due to their ability to immortalize spontaneously, were exploited to identify genes associated with cellular mortal or immortal phenotypes. Independent studies on spontaneously immortalized clones from different strains of mouse have shown that most of these clones had one or both mutant p53 alleles, in contrast to their parent cells which expressed wild type p53. The immortal clones which expressed wild type p53 were found to be defective in one or other elements of the pRb pathway.
Creative Bioarray can provide you immortalized murine cell lines with an integrated platform for meeting the needs for virtually any relevant research project.
Description: The Immortalized Mouse Mammary Epithelial Cells (iMMEC) is derived by co-expression...
Description: The Immortalized Mouse Prostate Epithelial Cells (iMPEC, clone7) is derived by co-expression...
Description: YAMC is a conditionally immortalized mouse colon epithelial cell line isolated from...
Description: The Immortalized Ovarian Surface Epithelial Cells (iMOSEC) is derived by co-expression...
Description: The mammalian cerebellum is indispensable in the coordination of voluntary movement...
Description: The Immortalized Baby Mouse Kidney Epithelial Cells (iBMK, Clone W2) is derived by...
Description: ImSt is a conditionally immortalized mouse stomach epithelial cell line isolated...
Description: IMPE is a conditionally immortalized mouse pancreas epithelial cell line isolated...
Description: MSIE is a conditionally immortalized mouse small intestine epithelial cell line isolated...
Description: The epididymal epithelium plays an important role in male fertility by supporting...
Description: ImHep is a conditionally immortalized mouse hepatocyte isolated from the mouse harboring...
Description: The Immortalized Rat Retinal Precursor Cell Line (R28) is derived from postnatal...
Description: Clara cells play a role in the maintenance of normal bronchiolar epithelium by secreting...
Description: Müller cells are glial cells in the vertebrate retina responsible for the homeostatic...
Description: Nonciliated bronchiolar (Clara) cells, alveolar type I and type II cells are the...
Description: The Immortalized Rat Conjunctival Epithelial Cells (CJ4.3) were derived from primary...
Description: The epididymal epithelium plays an important role in male fertility by supporting...
Description: Microglia cells are resident macrophages of the brain and spinal cord and they act...
