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Tumor cells acquire invasive and metastatic abilities through genetic changes that enable them to degrade the extracellular matrix, invade surrounding tissues, enter the bloodstream or lymphatic system, and establish secondary tumors in distant organs. This process, known as metastasis, is a major challenge in cancer treatment.
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Average Rating: 5.0 | 1 Scientist has reviewed this product
Amazing performance
I'm amazed at the performance of this cell product. The cells were highly viable, and their functionality was preserved.
15 June 2023
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Description: FTC-133 was isolated from a lymph node metastasis of a follicular thyroid carcinoma. The morphology differs from flat polygonal to spindle formed cells. They retained differentiated thyrocyte function and thyrocyte responsiveness to thyrotropin and local active growth factors. Thyroglobulin immunoreactivity could be shown in the cytoplasm and EGF receptor immunoreactivity could be visualised on the cell membranes. Complex chromosomal changes were detected as well as a p53 mutation.
Description: Species: human male 42 years old;
Tissue: thyroid;
Tumor: carcinoma, follicular;
Derived from: lung metastasis
Description: Established from the primary tumor of a 67-year-old woman with primary thyroid carcinoma (undifferentiated carcinoma, composed of spindle, polygonal and giant cells)
Description: Established from the sarcoma of the thyroid gland from a 47-year-old woman in 1985
Description: Established from the tumor tissue of a 76-year-old woman with metastasizing papillary thyroid carcinoma in 1992
