Hepatocytes

Hepatocytes are the chief functional cells of the liver, responsible for the selective uptake, metabolism and excretion of most drugs. Cells for use in plate cultures or suspension assays represent a key tool for predicting properties such as hepatotoxicity, metabolism, and potential drug-drug interactions. Since these cells mimic the properties of the liver, researchers can evaluate the metabolism, drug-drug interaction and toxicity of drug candidates in a cost-effective manner.

Human Hepatocytes

In drug development, primary human hepatocytes are the most suitable system for uptake, metabolism, clearance, hepatotoxicity, drug-drug interaction, and other preclinical in vitro studies. We have fresh, cryopreserved, and immortalized lines available.

Animal Hepatocytes

Primary animal hepatocytes provide a cost-effective alternative to human hepatocytes for in vitro drug metabolism studies. We offer fresh and cryopreserved pools from a wide variety of species.

Kupffer Cells

Kupffer Cells are a specialized, liver-derived primary immune cell test system commonly used to investigate macrophage activity for in vitro drug metabolism assays.

Cell Culture Medium

To complement the widest selection of DMPK test systems on the market, we provide optimized media and reagents specially formulated for isolating, thawing, incubating, plating, and culturing cell test systems including hepatocytes, Kupffer cells, and more.