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Immortalized Human Schwann Cells-SV40T
Cat.No.: CSC-I2111Z
Species: Homo sapiens
Morphology: Polygonal
Culture Properties: Adherent
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Note: Never can cells be kept at -20°C.
Immortalized Human Schwann Cells-SV40T are human Schwann cells that have been genetically modified with the SV40 large T antigen to enable continuous growth and division. This immortalization process allows for extended research use and reliable data generation.
These cells are ideally suited for research in neuroscience, particularly in studies of nerve regeneration and peripheral neuropathies. They provide an excellent model for testing therapeutic compounds, exploring myelination processes, and conducting neurotoxicology assessments.
These cells offer consistent, long-term usability without the drawbacks of primary cell culture, such as limited life span and variability. Their immortalized nature facilitates reproducibility and scalability in experiments, critical for robust scientific research.
Yes, the uniformity and reproducibility of these cells make them highly suitable for drug screening and testing, particularly for compounds targeting nerve repair and neuroprotection, enhancing the discovery of effective therapies.
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Description: Immortalized Human Umbilical Vein Endothelial Cells-hTERT were developed from human tissues transduced with a lentiviral expression vector containing the hTERT gene. The cell line was continuously cultured for more than 20 passages without showing signs of growth retardation or replicative senescence. The Immortalized Human Umbilical Vein Endothelial Cells are useful for setting up in vitro bioassays for studying angiogenesis in e.g. wound healing or metastasis as well as bioassays for testing the angiogenic properties of novel drugs. Additionally, the cell line is the perfect starting material for genetic engineering to create important disease models.
