Featured Products
Our Promise to You
Guaranteed product quality, expert customer support
ONLINE INQUIRY
Immortalized Human Hepatic Sinusoidal Endothelial Cells
Cat.No.: CSC-I9188L
Species: Homo sapiens
Source: Liver
Morphology: Cobblestone-like
Culture Properties: Adherent
- Specification
- Q & A
- Customer Review
SEC are microvascular endothelial cells with a unique phenotype reminiscent of dendritic cells and a unique function as antigenpresenting cells for CD4+ T cells. Thus, SEC represent a new type of organ resident "nonprofessional" antigenpresenting cell that appears to be involved in the local control of the immune response and the induction of immune tolerance in the liver. Primary SEC express well characterized surface receptors and differ morphologically and metabolically from largevessel endothelia. It has reported that SEC are dynamic regulators of porosity that respond rapidly and locally to environmental zonal stimuli during liver regeneration.
Note: Never can cells be kept at -20°C.
These are human hepatic sinusoidal endothelial cells that have been genetically modified to go beyond 30 passages, providing a stable and consistent in vitro model for research on liver endothelial functions and diseases.
Immortalized Human Hepatic Sinusoidal Endothelial Cells (Cat No.: CSC-I9188L) are perfect for studying liver microcirculation, endothelial cell function within the liver, liver fibrosis, drug metabolism, toxicology studies, and vascular biology in hepatic contexts.
Unlike primary hepatic endothelial cells, which have a limited lifespan and batch variability, these immortalized cells offer a reproducible and stable model, facilitating long-term studies and consistent experimental outcomes.
Ask a Question
Write your own review
Description: Microglia cells are resident macrophages of the brain and spinal cord and they act as the first and the main form of active immune defense in the nervous system. The Immortalized Human Microglia - SV40 cell line is derived from Primary Human Microglia Cells (>99% purity) and have maintained microglial marker TREM2 as demonstrated by RT-PCR. These cells are suitable for studies of human microglia in health and disease.
Description: Immortalized Human Umbilical Vein Endothelial Cells-hTERT were developed from human tissues transduced with a lentiviral expression vector containing the hTERT gene. The cell line was continuously cultured for more than 20 passages without showing signs of growth retardation or replicative senescence. The Immortalized Human Umbilical Vein Endothelial Cells are useful for setting up in vitro bioassays for studying angiogenesis in e.g. wound healing or metastasis as well as bioassays for testing the angiogenic properties of novel drugs. Additionally, the cell line is the perfect starting material for genetic engineering to create important disease models.
