Type II Collagenase-Induced Osteoarthritis (OA) Model

Creative Bioarray possesses the requisite expertise and extensive pharmaceutical industry experience to assist our clients in assessing the therapeutic potential of test agents for the treatment of osteoarthritis (OA). We have successfully developed a highly stable OA model, induced by type II collagenase. Our model is designed to accurately simulate the pathophysiological conditions of OA, enabling precise evaluation of the efficacy and safety of novel therapeutic candidates.

OA is the most prevalent degenerative joint disorder, affecting critical joint components such as articular cartilage, synovium, and subchondral bone. A comprehensive understanding of OA's pathophysiological mechanisms is vital for the advancement of more effective treatments. Collagenase plays a significant role in the induction of knee osteoarthritis, primarily targeting joint structures like tendons and ligaments, which are rich in collagen type 1. This enzyme's action leads to joint instability, with minimal direct impact on joint cartilage. The injection of collagenase into the joint cavity serves as a method to experimentally induce OA, offering valuable insights into the disease's progression and potential therapeutic targets.

Our Type II Collagenase-Induced Osteoarthritis (OA) Model

• Available Animal

Rat

• Modeling Method

After anesthetization, rats are given the intra-articular injection of type II collagenase on day 1 and day 4.

• Endpoints

• Behavioral test: open filed test
• Histology analysis: H&E staining
• Mankin score
• Other customized endpoints

Example Data

Fig. 1 Histopathological changes (H&E stain) in the knee joint after ChondroT administration in collagenase induced arthritis rats. a Intact, b Control, c Indomethacin, d Joins Tab, e ChondroT50, f ChondroT100, g ChondroT200. (Jeong et al. 2018)

In addition, we also provide other OA models that maybe you are interested in:

• Monosodium Iodoacetate (MIA)-Induced Osteoarthritis (OA) Model
• Papain-Induced Osteoarthritis (OA) Model
• Medial Meniscal Tear (MMT)-Induced Osteoarthritis (OA) Model
• Anterior Cruciate Ligament Transection (ACLT)-Induced Osteoarthritis (OA) Model

Quotation and Ordering

Creative Bioarray is committed to enhancing our in vivo pharmacology capabilities. We are dedicated to meeting the unique requirements of our clients by offering customized models tailored to their specific compound or discovery program. If you are interested in our services, please feel free to contact us at any time or submit an inquiry to us directly.

Reference

1. Jeong, J., et al. Anti-osteoarthritic effects of ChondroT in a rat model of collagenase-induced osteoarthritis. BMC complementary and alternative medicine, 2018, 18: 1-10.

Explore Other Options

• Osteoarthritis (OA) Model
• Osteoporosis Model

• Anterior Cruciate Ligament Transection (ACLT)-Induced Osteoarthritis (OA) Model
• Medial Meniscal Tear (MMT)-Induced Osteoarthritis (OA) Model
• Monosodium Iodoacetate (MIA)-Induced Osteoarthritis (OA) Model
• Papain-Induced Osteoarthritis (OA) Model

For research use only. Not for any other purpose.