Endothelial Cells

Endothelial Cells and Media

Endothelial cells are cells that line the inner surface of blood vessels and lymphatic vessels, forming an interface between circulating blood or lymph in the lumen and the rest of the vessel wall. The endothelial cells serve as a permeable barrier to regulate the passage of substances between blood-stream and surrounding tissue. In basic research, endothelial cells are critical in applications related to wound healing, angiogenesis, blood brain barrier (BBB), inflammatory processes, diabetes and other cardiovascular diseases.

Human Umbilical Vein Endothelial Cells (HUVECs)

The human umbilical cord has become one of the most important sources of vascular endothelial cells. The availability of these cells has played a major role in the development of the field of vascular biology.

HUVECs have provided a critical in vitro model for major breakthroughs in the pathophysiology of atherosclerosis and plaque formation, and mechanisms for the control of angiogenesis or neovascularization in response to hypoxia and inflammation in tumors, ischemic tissue, and in embryogenesis.

Coronary Artery Endothelial Cells (CAECs)

The coronary arteries provide abundant blood supply to meet the enormous energy demands of the heart’s sustained contraction activity. Coronary artery endothelial cells (CAECs) are continuously exposed to fluid shear stress, causing changes in cell morphology and producing endothelium-derived substances that regulate vasoconstriction and vessel growth. CAECs can also modulate the expression of cellular adhesion molecules to control and fine-tune inflammatory response and fibrinolysis. These physiological properties make CAECs widely used in the study of mechanisms for endothelium dysfunction, pathogenesis of coronary heart disease and atherosclerosis, and the development of novel disease treatments.

Aortic Endothelial Cells (AECs)

The aorta is the largest artery in the body, which transports oxygenated blood from the heart to all parts of the body. Aortic endothelial cells (AECs) provide an excellent model system for studying cardiovascular function and disease, and they have been used in research of diabetes-associated complications related to cardiovascular function, immune response mechanisms and graft rejection, as well as 3D endothelialized engineering tissues.

Human Lung Microvascular Endothelial Cells (HLMECs)

The lung microvascular endothelial cells (LMECs) are isolated from human pulmonary arteries. The LMECs form a semi-selective barrier that is essential for gas exchange and regulation of fluid and solute passage between blood and interstitial compartments in the lung.

HLMECs have been used to study the pathology and biology of the pulmonary microvasculature in vitro. The pulmonary vasculature is of great physiological/pathological significance, which is recognized to be a tissue composed of metabolically active, functionally responsive cells that interact with the circulating matrix and regulate the composition of systemic arterial blood, affect target organ functions, and contribute to thrombosis, hemostasis and immune reactions, as well as tumor metastasis.

At Creative Bioarray, we provide a reliable and reproducible endothelial cell resources for vascular disease modeling, drug screening, and vascular tissue engineering applications.

Endothelial cells from Creative Bioarray have been isolated from human normal, diseased donors of various tissues and animals such as mouse, rat, monkey and bovine with high purity, low passage, rigorous characterization and performance tested. Those cells have numerous applications as below: