ActoFactor™ Human Fms-like tyrosine kinase-3

Specification

Cat.No.

CSC-CTK0009G

Description

FMS-like Tyrosine Kinase 3 is a cytokine that regulates proliferation and differentiation of various blood cell progenitors. It is used in the cell and gene therapy space for the ex vivo expansion of HSCs that are used for transplantation.

Source

E coli.

Sequence

TQDCSFQHSP ISSDFAVKIR ELSDYLLQDY PVTVASNLQD EELCGGLWRL VLAQRWMERL KTVAGSKMQG LLERVNTEIH FVTKCAFQPP PSCLRFVQTN ISRLLQETSE QLVALKPWIT RQNFSRCLEL QCQPDSSTLP PPWSPRPLEA TAPTA

Molecular Mass

Approximately 17.6 kDa, a single non-glycosylated polypeptide chain containing 155 amino acids

Size

5μg, 100μg, 500μg, 1000μg

Purity

> 98 %

Activity

Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human AML5 cells is less than 1.0 ng/ml, corresponding to a specific activity of > 1.0 × 106 IU/mg.

Endotoxin Level

<0.01EU/μg

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.

Usage

This GMP product can be for research use or further manufacturing use.(NOT FOR HUMAN USE)

Storage

Store lyophilized cytokine at -20°C to -80°C.
Avoid repeated freeze/thaw cycles.

Shipping

Dry ice

Citation Guidance

If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.

For research use only. Not for any other purpose.

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