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ActoFactor™ Recombinant Human Fibroblast growth factor 12
- Specification
Cat.No.
CSC-CTK0150
Description
FGF-12 is part of the Fibroblast Growth Factor (FGF) family which has a vast mitogenic and cell survival functions, and play a role in a range of biological activities, among them are embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. FGF-12 doesn't obtain the N-terminal signal sequence present in the majority of the FGF family members, but it contains clusters of basic residues that act as a nuclear localization signal. When transfected into mammalian cells, FGF-12 accumulated in the nucleus, but was not secreted. FGF-12 is involved in nervous system development and function. FGF-12 binds to IB-2 (islet brain-2), a cellular kinase scaffold, and voltage gated sodium channels and is also involved in intracellular signaling and ion exchange. Recombinant human FGF-12 is a single, non-glycosylated polypeptide chain produced in E. coli, having a molecular weight of 22.6 kDa and containing 201 amino acids (1-181). The FGF-12 is fused to a 20 amino acid His tag at the N-terminus.
Species
Human
Product Overview
Human FGF12 expressed in E.coli
Molecular Mass
22.6 kDa
Size
CAT# CSC-CTK0150-10 (10 μg); CAT# CSC-CTK0150-50 (50 μg)
Expression System
E.coli
Purity
Greater than 90% as determined by SDS-PAGE analysis.
Activity
N/A
Endotoxin Level
N/A
Formulation
The FGF-12 solution (1 mg/ml) contains 20 mM Tris (pH 7.5), 1 mM DTT, 2 mM EDTA and 10% glycerol.
Reconstitution
Please centrifuge product briefly before opening vial. The dissolved protein can be diluted into other aqueous buffers and stored at -20°C for future use.
Storage & Stability
Store at 4°C if entire vial will be used within 1 week. Store frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
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