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ActoFactor™ Recombinant Human Connective tissue growth factor (98 aa variant)
- Specification
Cat.No.
CSC-CTK0589
Description
CTGF is a member of the CCN family of secreted cysteine rich regulatory proteins and is the major mitogenic and chemoattractant protein produced by umbilical vein and vascular endothelial cells. CTGF stimulates the proliferation and differentiation of chondrocytes, induces angiogenesis, promotes cell adhesion of fibroblasts, endothelial, and epithelial cells, and binds to IGF, TGF beta1, and BMP-4. Cell migration and adhesion are signaled through binding to specific cell surface integrins and to heparin sulfate proteoglycans CTGF (98 a.a.), a lower molecular weight isoform containing the C-terminal portion of the full length CTGF protein, exerts full heparin binding, cell adhesion, and mitogenic CTGF activity. Recombinant human CTGF is a 11.2 kDa protein of 98 amino acid residues.
Species
Human
Product Overview
Human CTGF expressed in E.coli
Molecular Mass
11.2 kDa
Size
CAT# CSC-CTK0589-20 (20 μg); CAT# CSC-CTK0589-100 (100 μg)
Expression System
E.coli
Purity
Greater than 95% as determined by SDS-PAGE analysis.
Activity
Determined by the dose-dependent stimulation of the proliferation of HUVEC cells. The expected ED50 for this effect is 1.0-2.0 μg/ml.
Endotoxin Level
Less than 1 EU/μg.
Formulation
CTGF was lyophilized from a sterile-filtered 1 mg/ml solution containing 10 mM Na-acetate buffer (pH 6).
Reconstitution
Please centrifuge product briefly before opening vial. Reconstitute at 0.1 mg/ml with 5 mM Na-acetate (pH 6). This solution can then be diluted into other aqueous buffers and stored at -20°C for future use.
Storage & Stability
The lyophilized protein, though stable at room temperature for up to 3 weeks, is best stored desiccated at -20°C. Reconstituted rHu CTGF should be used immediately or stored long-term in undiluted working aliquots at -20°C. Avoid repeated freeze-thaw cycles.
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
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