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TNFAIP3 FISH Probe
- Specification
Cat.No.
FONC-138
Description
TNFAIP3 FISH Probe is specifically designed to detect amplifications and deletions of the TNFAIP3 gene. This probe comes labeled in vibrant orange for optimal visualization, and we offer customization options to cater to your specific research requirements.
The TNFAIP3 (Tumor Necrosis Factor Alpha-Induced Protein 3), also known as A20, is a critical regulator of the inflammatory response and immune signaling pathways. It functions as a ubiquitin-editing enzyme that negatively regulates NF-κB signaling, thereby playing a fundamental role in maintaining immune homeostasis and preventing excessive inflammation. Aberrations in TNFAIP3, including gene amplifications or deletions, have been implicated in various autoimmune diseases and lymphoproliferative disorders.
Clinical Relevance: Detecting TNFAIP3 amplifications and deletions is crucial for understanding the molecular mechanisms underlying certain lymphomas, particularly diffuse large B-cell lymphoma (DLBCL) and other aggressive B-cell malignancies. Loss of TNFAIP3 function due to deletion or mutations can lead to uncontrolled NF-κB activity and increased survival of malignant cells, contributing to tumor progression.
Identifying these genetic changes can provide valuable insights into disease prognosis and may guide therapeutic decisions. Understanding the status of TNFAIP3 in tumors can also inform targeted treatment approaches, particularly in cases where the NF-κB pathway plays a significant role in tumorigenesis.
Our TNFAIP3 FISH Probe is an essential tool for researchers dedicated to elucidating the role of TNFAIP3 in cancer biology and advancing personalized treatment strategies in oncology.
The TNFAIP3 (Tumor Necrosis Factor Alpha-Induced Protein 3), also known as A20, is a critical regulator of the inflammatory response and immune signaling pathways. It functions as a ubiquitin-editing enzyme that negatively regulates NF-κB signaling, thereby playing a fundamental role in maintaining immune homeostasis and preventing excessive inflammation. Aberrations in TNFAIP3, including gene amplifications or deletions, have been implicated in various autoimmune diseases and lymphoproliferative disorders.
Clinical Relevance: Detecting TNFAIP3 amplifications and deletions is crucial for understanding the molecular mechanisms underlying certain lymphomas, particularly diffuse large B-cell lymphoma (DLBCL) and other aggressive B-cell malignancies. Loss of TNFAIP3 function due to deletion or mutations can lead to uncontrolled NF-κB activity and increased survival of malignant cells, contributing to tumor progression.
Identifying these genetic changes can provide valuable insights into disease prognosis and may guide therapeutic decisions. Understanding the status of TNFAIP3 in tumors can also inform targeted treatment approaches, particularly in cases where the NF-κB pathway plays a significant role in tumorigenesis.
Our TNFAIP3 FISH Probe is an essential tool for researchers dedicated to elucidating the role of TNFAIP3 in cancer biology and advancing personalized treatment strategies in oncology.
Size
10 Tests; 20 Tests
Label
Orange/Green/Aqua
Locus
6q23.3
Specificity
Human
Usage
For Research Use Only. Not for use in diagnostic procedures.
Storage
Store at minus 20 centigrade in the dark
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
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