SuperQuick® Cytochrome P450 3A4 (CYP3A4) Inhibitor Screening Kit

DMK-YS002

CYP3A4 is abundantly expressed in the liver and intestine, where it catalyzes the oxidation of a variety of structurally different ligands. Of all small molecule drugs commonly used in humans, more than half are metabolized by CYP3A4, and inhibition of CYP3A4-mediated metabolism is a common cause of drug/drug and drug/food interactions and toxicity.In addition, for the pharmacological activity of a drug to be metabolized from the prodrug form, inhibition of CYP3A4 can lead to decreased drug efficacy.Creative Bioarray's CYP3A4 Inhibitor Screening Kit allows rapid screening of compound-CYP3A4 interactions in a high-throughput fluorescent assay.

Perform rapid, high-throughput screening and characterization of compound interactions with CYP3A4.
Predict the adverse drug interaction potential and bioavailability of compounds metabolized by CYP3A4.

Simple and ready to use;
Rapid and high-throughput;
Hight sensitive.

Chemical compounds

CYP3A4 Assay Buffer
Resorufin Standard (5 mM in DMSO);
CYP3A4 Inhibitor (Ketoconazole);
NADPH Generating System(100X);
β-NADP+Stock (100X);
CYP3A4 Substrate;
Recombinant Human CYP3A4.

200 assys

Strore at -20℃.

Gel Pack

If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.