SuperQuick® Cytochrome P450 2D6 (CYP2D6) Inhibitor Screening Kit

DMK-YS004

CYP2D6 catalyzes the activation of lipophilic bases with an aromatic ring and a nitrogen atom, and is highly expressed in liver and brain tissues. This enzyme is involved in the metabolism of nearly 25% of commonly used small molecule drugs, particularly psychiatric drugs such as antidepressants, antipsychotics and stimulants.The CYP2D6 gene is highly polymorphic in the human population, making CYP2D6 frequently associated with drug toxicity and clinical drug/drug interactions. In addition, inhibitions or allelic deficiencies of CYP2D6 can lead to reduced drug efficacy for drugs whose pharmacological activity requires metabolism from the prodrug form.Creative Bioarray's CYP2D6 Inhibitor Screening Kit provides rapid screening of compound-CYP2D6 interactions in a high-throughput fluorescent assay.

Perform rapid, high-throughput screening and characterization of compound interactions with CYP2D6.
Predict the adverse drug interaction potential and bioavailability of compounds metabolized by CYP2D6.

Simple and ready to use;
Rapid and high-throughput;
Hight sensitive.

Chemical compounds

CYP2D6 Assay Buffer;
AHMC Standard;
CYP2D6 Inhibitor (Quinidine);
NADPH Generating System (100X);
β-NADP+Stock (100X);
CYP2D6 Substrate;
Recombinant Human CYP2D6.

200 assys

Strore at -20℃.

Gel Pack

If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.